Publications in scientific journals: 2016

Research based on NTR data

2016

Adams HHH, Hibar DP, Chouraki V, Stein JL, Nyquist PA, Renteria ME, Trompet S, Arias-Vasquez A, Seshadri S, Desrivieres S, Braber A den, Geus EJC de, Boomsma DI, Fedko IO, Hottenga JJ, Hulshoff Pol HE, Penninx BWJH, Craen AJM de, Wright MJ, Launer LJ, Schumann G, Fornage M, Franke B, Debette S, Medland SE, Ent D van 't, Arfan Ikram M, Thompson PM, many others. Novel genetic loci underlying human intracranial volume identified through genome-wide association. Nature Neuroscience. 2016;19(12):1569-1582
DOI: 10.1038/nn.4398
Supplementary Materials (zip file)

Amin N, Allebrandt KV, Spek A van der, Müller-Myhsok B, Hek K, Teder-Laving M, Hayward C, Esko T, Mill JG van, Mbarek H, Hottenga JJ, Vink JM, Boomsma DI, Martin NG, Rudan I, Tiemeier H, IJcken WFJ van, Penninx BWJH, Metspalu A, Meitinger T, Franke L, Roenneberg T, Duijn CM van, many others. Genetic variants in RBFOX3 are associated with sleep latency. European Journal of Human Genetics. 2016;24(10):1488-1495
DOI: 10.1038/ejhg.2016.31
Supplementary Materials (zip file)

Antonakakis M, Zervakis M, Beijsterveldt CEM van, Boomsma DI, Geus EJC de, Micheloyannis S, Smit DJA. Genetic effects on source level evoked and induced oscillatory brain responses in a visual oddball task. Biological Psychology. 2016;114:69-80
DOI: 10.1016/j.biopsycho.2015.12.006
Supplementary Materials (zip file)

Barban N, Jansen R, Vlaming R de, Vaez A, Mandemakers JJ, Tropf FC, Shen X, Wilson JF, Chasman DI, Nolte IM, BIOS Consortium, Mbarek H, Boomsma DI, Geus EJC de, LifeLines Cohort Study, Penninx BWJH, Willemsen G, Zondervan KT, Stefansson K, Krueger RF, Lee JJ, Benjamin DJ, Cesarini D, Koellinger PD, Hoed M den, Snieder H, Mills MC, many others. Genome-wide analysis identifies 12 loci influencing human reproductive behavior. Nature Genetics. 2016;48(12):1462-1472
DOI: 10.1038/ng.3698
Supplementary Materials (zip file)

Beijsterveldt CEM van, Overbeek LIH, Rozendaal L, McMaster MTB, Glasner TJ, Bartels M, Vink JM, Martin NG, Dolan CV, Boomsma DI. Chorionicity and Heritability Estimates from Twin Studies: The Prenatal Environment of Twins and Their Resemblance Across a Large Number of Traits. Behavior Genetics. 2016;46(3):304-314
DOI: 10.1007/s10519-015-9745-3
Supplementary Materials (zip file)

Berg SM van den, Moor MHM de, Verweij KJH, Krueger RF, Luciano M, Vasquez AA, Matteson LK, Derringer J, Esko T, Amin N, Abdellaoui A, Davies G, Fedko IO, Hottenga JJ, Mbarek H, Milaneschi Y, Nivard MG, Ouwens KG, Grabe HJ, Penninx BWJH, Duijn CM van, Evans DM, Schlessinger D, Pedersen NL, Terracciano A, McGue M, Martin NG, Boomsma DI, many others. Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium. Behavior Genetics. 2016;46(2):170-182
DOI: 10.1007/s10519-015-9735-5
Supplementary Materials (zip file)

Bovenberg J, Kattenberg VM, Baselmans BML, Sinke M, Hoekstra R, Boomsma DI, Willemsen G. Enhancing Biobank Participants' Rights - From Paper to Portal. SCRIPTed. 2016;13(1):70-82
DOI: 10.2966/scrip.130116.70

Braber A den, Zilhão NR, Fedko IO, Hottenga JJ, Pool R, Smit DJA, Cath DC, Boomsma DI. Obsessive–compulsive symptoms in a large population-based twin-family sample are predicted by clinically based polygenic scores and by genome-wide SNPs. Translational Psychiatry. 2016;6(e731), Open
DOI: 10.1038/tp.2015.223
Supplementary Materials (zip file)

Chen J, Bacanu SA, Yu H, Zhao Z, Jia P, Kendler KS, Kranzler HR, Gelernter J, Farrer L, Minica C, Pool R, Milaneschi Y, Boomsma DI, Penninx BWJH, Tyndale RF, Ware JJ, Vink JM, Kaprio J, Munafò M, Chen X, Cotinine meta-analysis group, FTND meta-analysis group. Genetic Relationship between Schizophrenia and Nicotine Dependence. Scientific Reports. 2016;6(25671), Open
DOI: 10.1038/srep25671
Supplementary Materials (zip file)

Dekkers KF, Iterson M van, Slieker RC, Moed MH, Bonder MJ, Galen M van, Mei H, Zhernakova DV, Berg LH van den, Deelen J, Dongen J van, Heemst D van, Hofman A, Hottenga JJ, Kallen CJH van der, Schalkwijk CG, Stehouwer CDA, Tigchelaar EF, Uitterlinden AG, Willemsen G, Zhernakova A, Franke L, Hoen PAC ’t, Jansen R, Meurs J van, Boomsma DI, Duijn CM van, Greevenbroek MMJ van, Veldink JH, Wijmenga C, BIOS Consortium, Zwet EW van, Slagboom PE, Jukema JW, Heijmans BT. Blood lipids influence DNA methylation in circulating cells. Genome Biology. 2016;17(138):1-12, Open
DOI: 10.1186/s13059-016-1000-6
Supplementary Materials (zip file)

Dolan CV, Geels LM, Vink JM, Beijsterveldt CEM van, Neale MC, Bartels M, Boomsma DI. Testing Causal Effects of Maternal Smoking During Pregnancy on Offspring’s Externalizing and Internalizing Behavior. Behavior Genetics. 2016;46(3):378-388, Open
DOI: 10.1007/s10519-015-9738-2

Dongen J van, Nivard MG, Willemsen G, Hottenga JJ, Helmer Q, Dolan CV, Ehli EA, Davies GE, Iterson M van, Breeze CE, Beck S, BIOS Consortium, Suchiman HE, Jansen R, Meurs JB van, Heijmans BT, Slagboom PE, Boomsma DI. Genetic and environmental influences interact with age and sex in shaping the human methylome. Nature Communications. 2016;(11115):1-13, Open
DOI: 10.1038/ncomms11115
Supplementary Materials (zip file)

Doornweerd S, IJzerman RG, Eijk L van der, Neter JE, Dongen J van, Ploeg HP van der, Geus EJC de. Physical activity and dietary intake in BMI discordant identical twins. Obesity. 2016;24(6):1349-1355
DOI: 10.1002/oby.21475

Ehret GB, Ferreira T, Chasman DI, Jackson AU, Schmidt EM, Johnson T, Thorleifsson G, Luan J, Donnelly LA, Kanoni S, Jansen R, CHARGE-EchoGen Consortium, CHARGE-HF Consortium, Wellcome Trust Case Control Consortium, Boomsma DI, Hottenga JJ, Penninx BWJH, Duijn CM van, Wichmann HE, Palmer CNA, Stefansson K, Ridker PM, Loos RJF, Chakravarti A, Deloukas P, Morris AP, Newton-Cheh C, Munroe PB, many others. The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nature Genetics. 2016;48(10):1171-1184
DOI: 10.1038/ng.3667
Supplementary Materials (zip file)

Eising E, Huisman SMH, Mahfouz A, Vijfhuizen LS, Anttila V, Winsvold BS, Kurth T, Arfan Ikram M, Freilinger T, Kaprio J, Boomsma DI, Duijn CM van, Järvelin MR, Zwart JA, Quaye L, Strachan DP, Kubisch C, Dichgans M, Davey Smith G, Stefansson K, Palotie A, Chasman DI, Ferrari MD, Terwindt GM, Vries B de, Nyholt DR, Lelieveldt BPF, Maagdenberg AMJM van den, Reinders MJT. Gene co-expression analysis identifies brain regions and cell types involved in migraine pathophysiology: a GWAS-based study using the Allen Human Brain Atlas. Human Genetics. 2016;135(4):425-439, Open
DOI: 10.1007/s00439-016-1638-x
Supplementary Materials (zip file)

Felix JF, Bradfield JP, Monnereau C, Valk RJP van der, Stergiakouli E, Chesi A, Gaillard R, Feenstra B, Thiering E, Kreiner-Møller E, Groen-Blokhuis MM, Bone Mineral Density in Childhood Study (BMDCS), Early Genetics and Lifecourse Epidemiology (EAGLE) consortium, Hottenga JJ, Middeldorp CM, Boomsma DI, Heinrich J, Melbye M, Rivadeneira F, Hakonarson H, Ring SM, Davey Smith G, Sørensen TIA, Timpson NJ, Grant SFA, Jaddoe VWV, many others for the Early Growth Genetics (EGG) Consortium. Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index. Human Molecular Genetics. 2016;25(2):389-403
DOI: 10.1093/hmg/ddv472
Supplementary Materials (zip file)

Forde NJ, Kanaan AS, Widomska J, Padmanabhuni SS, Nespoli E, Alexander J, Rodriguez Arranz JI, Fan S, Houssari R, Nawaz MS, Rizzo F, Pagliaroli L, Zilhão NR, Aranyi T, Barta C, Boeckers TM, Boomsma DI, Buisman WR, Buitelaar JK, Cath D, Dietrich A, Driessen N, Drineas P, Dunlap M, Gerasch S, Glennon J, Hengerer B, Heuvel OA van den, Jespersgaard C, Möller HE, Müller-Vahl KR, Openneer TJC, Poelmans G, Pouwels PJW, Scharf JM, Stefansson H, Tümer Z, Veltman DJ, Werf YD van der, Hoekstra PJ, Ludolph A, Paschou P. TS-EUROTRAIN: A European-Wide Investigation and Training Network on the Etiology and Pathophysiology of Gilles de la Tourette Syndrome. Frontiers in Neuroscience. 2016;10:Article 384
DOI: 10.3389/fnins.2016.00384

Franke B, Stein JL, Ripke S, Anttila V, Hibar DP, Hulzen KJE van, Arias-Vasquez A, Smoller JW, Nichols TE, Neale MC, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Enigma Consortium, Braber A den, Fedko IO, Hottenga JJ, Ent D van ’t, Boomsma DI, Geus EJC de, O'Donovan MC, Thompson PM, Neale BM, Medland SE, Sullivan PF, many others. Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept. Nature Neuroscience. 2016;19(3):420-431
DOI: 10.1038/nn.4228
Supplementary Materials (zip file)

Gale CR, Hagenaars SP, Davies G, Hill WD, Liewald DC, Cullen B, Penninx BWJH, International Consortium for Blood Pressure GWAS, CHARGE Consortium Aging and Longevity Group, Boomsma DI, Pell J, McIntosh AM, Smith DJ, Deary IJ, Harris SE. Pleiotropy between neuroticism and physical and mental health: findings from 108038 men and women in UK Biobank. Translational Psychiatry. 2016;6:e791
DOI: 10.1038/tp.2016.56
Supplementary Materials (zip file)

Gormley P, Anttila V, Winsvold BS, Palta P, Esko T, Pers TH, Farh KH, Cuenca-Leon E, Muona M, Furlotte NA, Ligthart L, Hottenga JJ, Penninx BWJH, International Headache Genetics Consortium, Boomsma DI, Davey Smith G, Stefansson K, Eriksson N, Daly MJ, Neale BM, Olesen J, Chasman DI, Nyholt DR, Palotie A. Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nature Genetics. 2016;48(8):856-866
DOI: 10.1038/ng.3598
Supplementary Materials (zip file)

Gusev A, Ko A, Shi H, Bhatia G, Chung W, Penninx BWJH, Jansen R, Geus EJC de, Boomsma DI, Wright FA, Sullivan PF, Nikkola E, Alvarez M, Civelek M, Lusis AJ, Lehtimäki T, Raitoharju E, Kähönen M, Seppälä I, Raitakari OT, Kuusisto J, Laakso M, Price AL, Pajukanta P, Pasaniuc B. Integrative approaches for large-scale transcriptome-wide association studies. Nature Genetics. 2016;48(3):245-252
DOI: 10.1038/ng.3506
Supplementary Materials (zip file)

Hagenbeek FA, Kluft C, Hankemeier T, Bartels M, Draisma HHM, Middeldorp CM, Berger R, Noto A, Lussu M, Pool R, Fanos V, Boomsma DI. Discovery of Biochemical Biomarkers for Aggression: A Role for Metabolomics in Psychiatry. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 171(5):719-732, Open
DOI: 10.1002/ajmg.b.32435
Supplementary Materials (zip file)

Hehir-Kwa JY, Marschall T, Kloosterman WP, Francioli LC, Baaijens JA, Dijkstra LJ, Abdellaoui A, Koval V, Thung DT, Wardenaar R, Renkens I, Coe BP, Deelen P, Ligt J de, Lameijer EW, Dijk F van, Hormozdiari F, The Genome of the Netherlands Consortium, Uitterlinden AG, Duijn CM van, Eichler EE, Bakker PIW de, Swertz MA, Wijmenga C, Ommen GJB van, Slagboom PE, Boomsma DI, Schönhuth A, Ye K, Guryev V. A high-quality human reference panel reveals the complexity and distribution of genomic structural variants. Nature Communications. 2016;7, Open
DOI: 10.1038/ncomms12989
Supplementary Materials (zip file)

Hodkinson EC, Neijts M, Sadrieh A, Imtiaz MS, Baumert M, Subbiah RN, Hayward CS, Boomsma DI, Willemsen G, Vandenberg JI, Hill AP, Geus EJC de. Heritability of ECG Biomarkers in the Netherlands Twin Registry Measured from Holter ECGs. Frontiers in Physiology. 2016;7(154)
DOI: 10.3389/fphys.2016.00154
Supplementary Materials (zip file)

Horikoshi M, Beaumont RN, Day FR, Warrington NM, Kooijman MN, Fernandez-Tajes J, Feenstra B, Zuydam NR van, Gaulton KJ, Grarup N, Hottenga JJ, Rahmioglu N, Nyholt DR, CHARGE Consortium Hematology Working Group, Beijsterveldt CEM van, Willemsen G, Early Growth Genetics (EGG) Consortium, Geus EJC de, Boomsma DI, Frayling TM, Davey Smith G, Morris AP, Ong KK, Felix JF, Timpson NJ, Perry JRB, Evans DM, McCarthy MI, Freathy RM, many others. Genome-wide associations for birth weight and correlations with adult disease. Nature. 2016;538(7624):248-252
DOI: 10.1038/nature19806
Supplementary Materials (zip file)

Howrigan DP, Simonson MA, Davies G, Harris SE, Tenesa A, Starr JM, Liewald DC, Deary IJ, McRae A, Wright MJ, Abdellaoui A, Boomsma DI, Burdick KE, Bitsios P, Donohoe G, Corley RP, Visscher PM, Pendleton N, Malhotra AK, Neale BM, Lencz T, Keller MC, others. Genome-wide autozygosity is associated with lower general cognitive ability. Molecular Psychiatry. 2016;21(6):837-843
DOI: 10.1038/mp.2015.120
Supplementary Materials (zip file)

Hugh-Jones D, Verweij KJH, St Pourcain B, Abdellaoui A. Assortative mating on educational attainment leads to genetic spousal resemblance for causal alleles. Intelligence. 2016;59:103-108
DOI: 10.1016/j.intell.2016.08.005

Huppertz C, Bartels M, Zeeuw EL de, Beijsterveldt CEM van, Hudziak JJ, Willemsen G, Boomsma DI, Geus EJC de. Individual Differences in Exercise Behavior: Stability and Change in Genetic and Environmental Determinants From Age 7 to 18. Behavior Genetics. 2016;46(5):665-679, Open
DOI: 10.1007/s10519-016-9799-x
Supplementary Materials (zip file)

Jansen R, Penninx BWJH, Madar V, Xia K, Milaneschi Y, Hottenga JJ, Hammerschlag AR, Beekman A, Wee N van der, Smit JH, Brooks AI, Tischfield J, Posthuma D, Schoevers R, Grootheest G van, Willemsen G, Geus EJC de, Boomsma DI, Wright FA, Zou F, Sun W, Sullivan PF. Gene expression in major depressive disorder. Molecular Psychiatry. 2016;21(3):339-347
DOI: 10.1038/mp.2015.57
Supplementary Materials (zip file)

Jelenkovic A, Sund R, Hur YM, Yokoyama Y, Hjelmborg JvB, Möller S, Honda C, Magnusson PKE, Pedersen NL, Ooki S, Bartels M, Beijsterveldt CEM van, Willemsen G, Kyvik KO, Christensen K, Öncel SY, Aliev F, Rasmussen F, Goldberg JH, Sørensen TIA, Boomsma DI, Kaprio J, Silventoinen K. Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts. Scientific Reports. 2016;6(Article number 28496):1-13, Open
DOI: 10.1038/srep28496
Supplementary Materials (zip file)

Jelenkovic A, Hur YM, Sund R, Yokoyama Y, Siribaddana SH, Hotopf M, Sumathipala A, Rijsdijk F, Tan Q, Zhang D, Bartels M, Beijsterveldt CEM van, Willemsen G, Iwatani Y, Watanabe M, Honda C, Inui F, Rasmussen F, Huibregtse BM, Boomsma DI, Sørensen TIA, Kaprio J, Silventoinen K, many others. Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994. eLIFE. 2016;5(e20320), Open
DOI: 10.7554/eLife.20320.001

Johnson EC, Bjelland DW, Howrigan DP, Abdellaoui A, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Sullivan PF, Keller MC. No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study. PLOS Genetics. 2016;12(10):e1006343, Open
DOI: 10.1371/journal.pgen.1006343
Supplementary Materials (zip file)

Kettunen J, Demirkan A, Würtz P, Draisma HHM, Haller T, Rawal R, Vaarhorst A, Kangas AJ, Lyytikäinen LP, Pirinen M, Pool R, Hottenga JJ, Willemsen G, Boomsma DI, Duijn CM van, Jula A, Järvelin MR, Kaprio J, Metspalu A, Raitakari O, Salomaa V, Slagboom PE, Waldenberger M, Ripatti S, Ala-Korpela M, many others. Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA. Nature Communications. 2016;7(11122):1-9, Open
DOI: 10.1038/ncomms11122
Supplementary Materials (zip file)

Knopik VS, Neiderhiser JM, Geus EJC de, Boomsma DI. The Importance of the Prenatal Environment in Behavioral Genetics: Introduction to Special Issue. Behavior Genetics. 2016;46(3):281-285
DOI: 10.1007/s10519-016-9790-6

Leeuwen EM van, Sabo A, Bis JC, Huffman JE, Manichaikul A, Smith AV, Feitosa MF, Demissie S, Joshi PK, Duan Q, Mbarek H, The LifeLines Cohort study, Geus EJC de, Milaneschi Y, Penninx BWJH, Willemsen G, CHARGE Lipids Working Group, Snieder H, Oldehinkel AJ, Slagboom PE, Boomsma DI, Wilson JG, Wilson JF, Gudnason V, Rich SS, Psaty BM, Borecki IB, Boerwinkle E, Rotter JI, Cupples LA, Duijn CM van. Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels. Journal of Medical Genetics. 2016;53(7):441-449, Open
DOI: 10.1136/jmedgenet-2015-103439
Supplementary Materials (zip file)

Li M, Rothwell R, Vermaat M, Wachsmuth M, Schröder R, Laros JFJ, Oven M van, Bakker PIW de, Bovenberg JA, Duijn CM van, Ommen GJB van, Slagboom PE, Swertz MA, Wijmenga C, Genome of the Netherlands Consortium, Kayser M, Boomsma DI, Zöllner S, Knijff P de, Stoneking M. Transmission of human mtDNA heteroplasmy in the Genome of the Netherlands families: support for a variable-size bottleneck. Genome Research. 2016;26(4):417-426
DOI: 10.1101/gr.203216.115
Supplementary Materials (zip file)

Lin BD, Hottenga JJ, Abdellaoui A, Dolan CV, Geus EJC de, Kluft C, Boomsma DI, Willemsen G. Causes of variation in the neutrophil-lymphocyte and platelet-lymphocyte ratios: a twin-family study. Biomarkers in Medicine. 2016;10(10):1061-1072
DOI: 10.2217/bmm-2016-0147

Lin BD, Willemsen G, Abdellaoui A, Bartels M, Ehli EA, Davies GE, Boomsma DI, Hottenga JJ. The Genetic Overlap Between Hair and Eye Color. Twin Research and Human Genetics. 2016;19(6):595-599
DOI: 10.1017/thg.2016.85
Supplementary Materials (zip file)

Lubke GH, Miller PJ, Verhulst B, Bartels M, Beijsterveldt CEM van, Willemsen G, Boomsma DI, Middeldorp CM. A powerful phenotype for gene-finding studies derived from trajectory analyses of symptoms of anxiety and depression between age seven and 18. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 2016;171(7):948-957, Open
DOI: 10.1002/ajmg.b.32375

Luo X, Stavrakakis N, Penninx BWJH, Bosker FJ, Nolen WA, Boomsma DI, Geus EJC de, Smit JH, Snieder H, Nolte IM, Hartman CA. Does refining the phenotype improve replication rates? A review and replication of candidate gene studies on Major Depressive Disorder and Chronic Major Depressive Disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 2016;171(2):215-236
DOI: 10.1002/ajmg.b.32396
Supplementary Materials (zip file)

Marceau K, McMaster MTB, Smith TF, Daams JG, Beijsterveldt CEM van, Boomsma DI, Knopik VS. The Prenatal Environment in Twin Studies: A Review on Chorionicity. Behavior Genetics. 2016;46(3):286-303, Open
DOI: 10.1007/s10519-016-9782-6
Supplementary Materials (zip file)

Marioni RE, Ritchie SJ, Joshi PK, Hagenaars SP, Okbay A, Fischer K, Adams MJ, Hill WD, Davies G, Social Science Genetic Association Consortium, Abdellaoui A, Hottenga JJ, Willemsen G, Boomsma DI, Nagy R, Amador C, Läll K, Metspalu A, Liewald DC, Campbell A, Wilson JF, Hayward C, Esko T, Porteous DJ, Gale CR, Deary IJ. Genetic variants linked to education predict longevity. Proceedings of the National Academy of Sciences. 2016;113(47):13366-13371
DOI: 10.1073/pnas.1605334113
Supplementary Materials (zip file)

Mbarek H, Steinberg S, Nyholt DR, Gordon SD, Miller MB, McRae AF, Hottenga JJ, Day FR, Willemsen G, Geus EJC de, Davies GE, Martin HC, Penninx BWJH, Jansen R, McAloney K, Vink JM, Kaprio J, Plomin R, Spector TD, Magnusson PK, Reversade B, Harris RA, Aagaard K, Kristjansson RP, Olafsson I, Eyjolfsson GI, Sigurdardottir O, Iacono WG, Lambalk CB, Montgomery GW, McGue M, Ong KK, Perry JRB, Martin NG, Stefansson H, Stefansson K, Boomsma DI. Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility. American Journal of Human Genetics. 2016;98(5):898-908, Open
DOI: 10.1016/j.ajhg.2016.03.008
Supplementary Materials (zip file)

Mbarek H, Dolan CV, Boomsma DI. Two SNPs Associated With Spontaneous Dizygotic Twinning: Effect Sizes and How We Communicate Them. Twin Research and Human Genetics. 2016;19(5):418-421
DOI: 10.1017/thg.2016.53
Supplementary Materials (zip file)

McCarthy S, Das S, Kretzschmar W, Delaneau O, Wood AR, Teumer A, Kang HM, Fuchsberger C, Danecek P, Sharp K, Boomsma DI, Slagboom PE, Walter K, Swaroop A, Cucca F, Anderson CA, Myers RM, Boehnke M, McCarthy MI, Durbin R, Abecasis G, Marchini J, many others for the Haplotype Reference Consortium. A reference panel of 64,976 haplotypes for genotype imputation. Nature Genetics. 2016;48(10):1279-1283
DOI: 10.1038/ng.3643
Supplementary Materials (zip file)

Middeldorp CM, Hammerschlag AR, Ouwens KG, Groen-Blokhuis MM, St Pourcain B, Greven CU, Pappa I, Tiesler CMT, Ang W, Nolte IM, Fedko IO, Hottenga JJ, Hudziak JJ, EArly Genetics and Lifecourse Epidemiology (EAGLE) Consortium, Psychiatric Genomics Consortium, ADHD Working Group, Nyholt DR, Medland SE, Neale BM, Jacobsson B, Sunyer J, Hartman CA, Whitehouse AJO, Pennell CE, Heinrich J, Plomin R, Davey Smith G, Tiemeier H, Posthuma D, Boomsma DI. A Genome-Wide Association Meta-Analysis of Attention-Deficit/Hyperactivity Disorder Symptoms in Population-Based Pediatric Cohorts. Journal of the American Academy of Child & Adolescent Psychiatry. 2016;55(10):896-905
DOI: 10.1016/j.jaac.2016.05.025
Supplementary Materials (zip file)

Milaneschi Y, Lamers F, Peyrot WJ, Abdellaoui A, Willemsen G, Hottenga JJ, Jansen R, Mbarek H, Dehghan A, Lu C, CHARGE inflammation working group, Boomsma DI, Penninx BWJH. Polygenic dissection of major depression clinical heterogeneity. Molecular Psychiatry. 2016;21(4):516-522
DOI: 10.1038/mp.2015.86
Supplementary Materials (zip file)

Miller R, Stalder T, Jarczok M, Almeida DM, Badrick E, Bartels M, Boomsma DI, Coe CL, Dekker MCJ, Donzella B, Fischer JE, Gunnar MR, Kumari M, Lederbogen F, Power C, Ryff CD, Subramanian SV, Tiemeier H, Watamura SE, Kirschbaum C. The CIRCORT database: Reference ranges and seasonal changes in diurnal salivary cortisol derived from a meta-dataset comprised of 15 field studies. Psychoneuroendocrinology. 2016;73:16-23
DOI: 10.1016/j.psyneuen.2016.07.201

Molenaar D, Middeldorp CM, Willemsen G, Ligthart L, Nivard MG, Boomsma DI. Evidence for Gender-Dependent Genotype by Environment Interaction in Adult Depression. Behavior Genetics. 2016;46(1):59-71, Open
DOI: 10.1007/s10519-015-9752-4

Nederend I, Schutte NM, Bartels M, Harkel ADJ ten, Geus EJC de. Heritability of heart rate recovery and vagal rebound after exercise. European Journal of Applied Physiology. 2016;116(11):2167-2176, Open
DOI: 10.1007/s00421-016-3459-y

Nieuwboer HA, Pool R, Dolan CV, Boomsma DI, Nivard MG. GWIS: Genome-Wide Inferred Statistics for Functions of Multiple Phenotypes. American Journal of Human Genetics. 2016;99(4):917-927
DOI: 10.1016/j.ajhg.2016.07.020
Supplementary Materials (zip file)

Nivard MG, Verweij KJH, Minica CC, Treur JL, International Cannabis Consortium, Vink JM, Boomsma DI. Connecting the dots, genome-wide association studies in substance use. Molecular Psychiatry. 2016;21(6):733-735
DOI: 10.1038/mp.2016.14

Nivard MG, Middeldorp CM, Lubke G, Hottenga JJ, Abdellaoui A, Boomsma DI, Dolan CV. Detection of gene-environment interaction in pedigree data using genome-wide genotypes. European Journal of Human Genetics, 24(12):1803-1809
DOI: 10.1038/ejhg.2016.88
Supplementary Materials (zip file)

Nivard MG, Boomsma DI. Genetics: From Molecule to Society. Current Biology. 2016;26(22):R1194-R1196, Open
DOI: 10.1016/j.cub.2016.09.064

Okbay A, Baselmans BML, Neve JE de, Turley P, Nivard MG, Fontana MA, Meddens SFW, Karlsson Linnér R, Rietveld CA, Derringer J, Minica CC, LifeLines Cohort Study, Hottenga JJ, Vinkhuyzen AE, Boomsma DI, Geus EJC de, Medland SE, Meyer MN, Pickrell JK, Esko, Krueger RF, Beauchamp JP, Koellinger PD, Benjamin DJ, Bartels M, Cesarini D, many others. Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. Nature Genetics. 2016;48(6):624-633
DOI: 10.1038/ng.3552
Supplementary Materials (zip file)

Okbay A, Beauchamp JP, Fontana MA, Lee JJ, Pers TH, Rietveld CA, Turley P, Chen GB, Emilsson V, Meddens SFW, Abdellaoui A, Peyrot WJ, Hottenga JJ, LifeLines Cohort Study, Vinkhuyzen AAE, Willemsen G, Boomsma DI, Penninx BWJH, Laibson DI, Medland SE, Meyer MN, Yang J, Johannesson M, Visscher PM, Esko T, Koellinger PD, Cesarini D, Benjamin DJ, many others. Genome-wide association study identifies 74 loci associated with educational attainment. Nature. 2016;533(7604):539-542
DOI: 10.1038/nature17671
Supplementary Materials (zip file)

Otowa T, Hek K, Lee M, Byrne EM, Mirza SS, Nivard MG, Bigdeli T, Aggen SH, Adkins D, Wolen A, Fanous A, Milaneschi Y, Hottenga JJ, Middeldorp CM, Penninx BWJH, Boomsma DI, Martin NG, Montgomery GW, Maher BS, Oord EJ van den, Wray NR, Tiemeier H, Hettema JM, others. Meta-analysis of genome-wide association studies of anxiety disorders. Molecular Psychiatry. 2016;21(10):1391-1399
DOI: 10.1038/mp.2015.197
Supplementary Materials (zip file)

Pappa I, St Pourcain B, Benke K, Cavadino A, Hakulinen C, Nivard MG, Nolte IM, Tiesler CMT, Bakermans-Kranenburg MJ, Davies GE, Groen-Blokhuis MM, Hudziak JJ, Whitehouse AJO, Davey Smith G, Heinrich J, Hypponen E, Lehtimäki T, Middeldorp CM, Oldehinkel AJ, Pennell CE, Boomsma DI, Tiemeier H, others. A genome-wide approach to children's aggressive behavior: The EAGLE consortium. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 2016;171(5):562-572, Open
DOI: 10.1002/ajmg.b.32333
Supplementary Materials (zip file)

Peyrot WJ, Boomsma DI, Penninx BWJH, Wray NR. Disease and Polygenic Architecture: Avoid Trio Design and Appropriately Account for Unscreened Control Subjects for Common Disease. American Journal of Human Genetics. 2016;98(2):382-391, Open
DOI: 10.1016/j.ajhg.2015.12.017
Supplementary Materials (zip file)

Pitsiladis YP, Tanaka M, Eynon N, Bouchard C, North KN, Williams AG, Collins M, Moran CN, Britton SL, Fuku N, Ashley EA, Klissouras V, Lucia A, Ahmetov II, Geus EJC de, Alsayrafi M, Athlome Project Consortium. Athlome Project Consortium: a concerted effort to discover genomic and other "omic" markers of athletic performance. Physiological Genomics. 2016;48(3):183-190, Open
DOI: 10.1152/physiolgenomics.00105.2015

Porsch RM, Middeldorp CM, Cherny SS, Krapohl E, Beijsterveldt CEM van, Loukola A, Korhonen T, Pulkkinen L, Corley R, Rhee S, Kaprio J, Rose RR, Hewitt JK, Sham P, Plomin R, Boomsma DI, Bartels M. Longitudinal heritability of childhood aggression. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 2016;171(5):697-707, Open
DOI: 10.1002/ajmg.b.32420

Quteineh L, Preisig M, Rivera M, Milaneschi Y, Castelao E, Gholam-Rezaee M, Vandenberghe F, Saigi-Morgui N, Delacrétaz A, Cardinaux JR, Willemsen G, Boomsma DI, Penninx BWJH, Ching-López A, Conus P, Eap CB. Association of CRTC1 polymorphisms with obesity markers in subjects from the general population with lifetime depression. Journal of Affective Disorders. 2016;198:43-49
DOI: 10.1016/j.jad.2016.03.031
Supplementary Materials (zip file)

Ricaño-Ponce I, Zhernakova DV, Deelen P, Luo O, Li X, Isaacs A, Karjalainen J, Di Tommaso J, Borek ZA, Zorro MM, Gutierrez-Achury J, Uitterlinden AG, Hofman A, Meurs J van, BIOS Consortium, Boomsma DI, Pool R, Dongen J van, Hottenga JJ, LifeLines Cohort Study, Neteaf MG, Jonkers IH, Withoff S, Duijn CM van, Li Y, Ruan Y, Franke L, Wijmenga C, Kumar V. Refined mapping of autoimmune disease associated genetic variants with gene expression suggests an important role for non-coding RNAs. Journal of Autoimmunity. 2016;68:62-74
DOI: 10.1016/j.jaut.2016.01.002
Supplementary Materials (zip file)

Ried JS, Jeff JM, Chu AY, Bragg-Gresham JL, Dongen J van, Huffman JE, Ahluwalia TS, Cadby G, Eklund N, Eriksson J, Geus EJC de, Hottenga JJ, Penninx BWJH, Willemsen G, Boomsma DI, McCarthy MI, North KE, O'Connell JR, Schlessinger D, Thorsteinsdottir U, Strachan DP, Frayling T, Hirschhorn JN, Müller-Nurasyid M, Loos RJF. A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape. Nature Communications. 2016;7(Article 13357), Open
DOI: 10.1038/ncomms13357
Supplementary Materials (zip file)

Roos L, Dongen J van, Bell CG, Burri A, Deloukas P, Boomsma DI, Spector TD, Bell JT. Integrative DNA methylome analysis of pan-cancer biomarkers in cancer discordant monozygotic twin-pairs. Clinical Epigenetics. 2016;8(7):1-16, Open
DOI: 10.1186/s13148-016-0172-y
Supplementary Materials (zip file)

Schumann G, Liu C, O’Reilly P, Gao H, Song P, Xu B, Ruggeri B, Amin N, Jia T, Preis S, Hottenga JJ, Mbarek H, Boomsma DI, Geus EJC de, Penninx BWJH, Bakalkin G, Evangelou E, Liu Y, Rice KM, Desrivieres S, Kliewer SA, Mangelsdorf DJ, Müller CP, Levy D, Elliott P, many others. KLB is associated with alcohol drinking, and its gene product B-Klotho is necessary for FGF21 regulation of alcohol preference. Proceedings of the National Academy of Sciences. 2016;113(50):14372-14377
DOI: 10.1073/pnas.1611243113
Supplementary Materials (zip file)

Schutte NM, Nederend I, Hudziak JJ, Geus EJC de, Bartels M. Differences in Adolescent Physical Fitness: A Multivariate Approach and Meta-analysis. Behavior Genetics. 2016;46(2):217-227, Open
DOI: 10.1007/s10519-015-9754-2

Schutte NM, Nederend I, Hudziak JJ, Bartels M, Geus EJC de. Twin-sibling study and meta-analysis on the heritability of maximal oxygen consumption. Physiological Genomics. 2016;48(3):210-219, Open
DOI: 10.1152/physiolgenomics.00117.2015

Schwabe I, Boomsma DI, Zeeuw EL de, Berg SM van den. A New Approach to Handle Missing Covariate Data in Twin Research. Behavior Genetics. 2016;46(4):583-595, Open
DOI: 10.1007/s10519-015-9771-1

Silventoinen K, Jelenkovic A, Sund R, Hur YM, Yokoyama Y, Honda C, Hjelmborg JvB, Möller S, Ooki S, Aaltonen S, Bartels M, Beijsterveldt CEM van, Baker LA, Tuvblad C, Duncan GE, Buchwald D, Willemsen G, Rasmussen F, Goldberg JH, Sørensen TIA, Boomsma DI, Kaprio J, many others. Genetic and environmental effects on body mass index from infancy to the onset of adulthood: an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study. The American Journal of Clinical Nutrition. 2016;104(2):371-379, Open
DOI: 10.3945/ajcn.116.130252
Supplementary Materials (zip file)

Silventoinen K, Huppertz C, Beijsterveldt CEM van, Bartels M, Willemsen G, Boomsma DI. The genetic architecture of body mass index from infancy to adulthood modified by parental education. Obesity. 2016;24(9):2004-2011, Open
DOI: 10.1002/oby.21588

Slieker RC, Iterson M van, Luijk R, Beekman M, Zhernakova DV, Moed MH, Mei H, Galen M van, Deelen P, Bonder MJ, Geus EJC de, Dongen J van, Jansen R, Hoen PAC 't, Franke L, Wijmenga C, Veldink JH, Swertz MA, Greevenbroek MMJ van, Duijn CM van, Boomsma DI, BIOS Consortium, Slagboom PE, Heijmans BT, others. Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms. Genome Biology. 2016;17:191, Open
DOI: 10.1186/s13059-016-1053-6

Smit DJA, Geus EJC de, Boersma M, Boomsma DI, Stam CJ. Life-Span Development of Brain Network Integration Assessed with Phase Lag Index Connectivity and Minimum Spanning Tree Graphs. Brain Connectivity. 2016;6(4):312-325
DOI: 10.1089/brain.2015.0359

Spjuth O, Krestyaninova M, Hastings J, Shen HY, Heikkinen J, Waldenberger M, Langhammer A, Ladenvall C, Esko T, Persson MÅ, Geus EJC de, Willemsen G, Hottenga JJ, Boomsma DI, Rung J, Palmgren J, Pedersen NL, McCarthy MI, Duijn CM van, Hveem K, Metspalu A, Ripatti S, Prokopenko I, Harris JR, others. Harmonising and linking biomedical and clinical data across disparate data archives to enable integrative cross-biobank research. European Journal of Human Genetics. 2016;24(4):521-528, Open
DOI: 10.1038/ejhg.2015.165
Supplementary Materials (zip file)

Stringer S, Minica CC, Verweij KJH, Mbarek H, Bernard M, Derringer J, Eijk KR van, Isen JD, Loukola A, Maciejewski DF, Abdellaoui A, Hottenga JJ, Huizink AC, Lubke GH, Nivard MG, Spector T, Munafò, Metspalu A, Gelernter J, Boomsma DI, Iacono WG, Martin NG, Gillespie NA, Derks EM, Vink JM, many others. Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium. Translational Psychiatry. 2016;(6):e769, Open
DOI: 10.1038/tp.2016.36
Supplementary Materials (zip file)

Swagerman SC, Geus EJC de, Kan KJ, Bergen E van, Nieuwboer HA, Koenis MM, Hulshoff Pol HE, Gur RE, Gur RC, Boomsma DI. The Computerized Neurocognitive Battery: Validation, aging effects, and heritability across cognitive domains. Neuropsychology. 2016;30(1):53-64
DOI: 10.1037/neu0000248
Supplementary Materials (zip file)

Swagerman SC, Bergen E van, Kan KJ, Koenis MMG, Hulshoff Pol HE, Boomsma DI, Geus EJC de. No Evidence of Causal Effects of Blood Pressure on Cognition in the Population at Large. Twin Research and Human Genetics. 2016;19(1):17-26
DOI: 10.1017/thg.2015.99

Treur JL, Taylor AE, Ware JJ, McMahon G, Hottenga JJ, Baselmans BML, Willemsen G, Boomsma DI, Munafò MR, Vink JM. Associations between smoking and caffeine consumption in two European cohorts. Addiction. 2016;111(6):1059-1068, Open
DOI: 10.1111/add.13298
Supplementary Materials (zip file)

Treur JL, Boomsma DI, Ligthart L, Willemsen G, Vink JM. Heritability of high sugar consumption through drinks and the genetic correlation with substance use. American Journal of Clinical Nutrition. 2016;104(4):1144-1150, Open
DOI: 10.3945/ajcn.115.127324
Supplementary Materials (zip file)

Tyrrell J, Richmond RC, Palmer TM, Feenstra B, Rangarajan J, Metrustry S, Cavadino A, Paternoster L, Armstrong LL, De Silva NMG, Hottenga JJ, Willemsen G, Geus EJC de, Hattersley AT, Scholtens DM, Davey Smith G, Hivert MF, Felix JF, Hyppönen E, Lowe Jr WL, Frayling TM, Lawlor DA, Freathy RM, many others for the Early Growth Genetics (EGG) Consortium. Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight. JAMA Journal of the American Medical Association. 2016;315(11):1129-1140, Open
DOI: 10.1001/jama.2016.1975
Supplementary Materials
(zip file)

Vinciotti V, Wit EC, Jansen R, Geus EJC de, Penninx BWJH, Boomsma DI, Hoen PAC ’t. Consistency of biological networks inferred from microarray and sequencing data. BMC Bioinformatics. 2016;17(254):1-10, Open
DOI: 10.1186/s12859-016-1136-0
Supplementary Materials (zip file)

Vink JM, Beijsterveldt CEM van, Huppertz C, Bartels M, Boomsma DI. Heritability of compulsive Internet use in adolescents. Addiction Biology. 2016;21(2):460-468, Open
DOI: 10.1111/adb.12218
Supplementary Materials (zip file)

Vries PS de, Chasman DI, Sabater-Lleal M, Chen MH, Huffman JE, Steri M, Tang W, Teumer A, Marioni RE, Grossmann V, Hottenga JJ, Willemsen G, Geus EJC de, Boomsma DI, Cucca F, Tracy R, Watkins H, Reiner AP, Folsom AR, Ridker PM, O'Donnell CJ, Smith NL, Strachan DP, Dehghan A, others. A meta-analysis of 120,246 individuals identifies 18 new loci for fibrinogen concentration. Human Molecular Genetics. 2016;25(2):358-370, Open
DOI: 10.1093/hmg/ddv454
Supplementary Materials (zip file)

Ware JJ, Chen X, Vink JM, Loukola A, Minica CC, Pool R, Milaneschi Y, Mangino M, Menni C, Chen J, Willemsen G, Hottenga JJ, Lehtimäki T, Kähönen M, Koskinen S, Spector TD, Penninx BWJH, Salomaa V, Boomsma DI, Tyndale RF, Kaprio J, Munafò MR, others. Genome-Wide Meta-Analysis of Cotinine Levels in Cigarette Smokers Identifies Locus at 4q13.2. Nature Scientific Reports. 2016;6(20092), Open
DOI: 10.1038/srep20092
Supplementary Materials (zip file)

Weiss A, Baselmans BML, Hofer E, Yang J, Okbay A, Lind PA, Miller MB, Nolte IM, Zhao W, Hagenaars SP, Hottenga JJ, Iacono WG, McGue M, Bennett DA, Pedersen NL, Magnusson PKE, Deary IJ, Martin NG, Boomsma DI, Bartels M, Luciano M, others. Personality Polygenes, Positive Affect, and Life Satisfaction. Twin Research and Human Genetics. 2016;19(5):407-417, Open
DOI: 10.1017/thg.2016.65
Supplementary Materials (zip file)

Wesseldijk LW, Dieleman GC, Lindauer RJL, Bartels M, Willemsen G, Hudziak JJ, Boomsma DI, Middeldorp CM. Spousal resemblance in psychopathology: A comparison of parents of children with and without psychopathology. European Psychiatry. 2016;34:49-55
DOI: 10.1016/j.eurpsy.2016.01.2423
Supplementary Materials (zip file)

Yang Y, Ligthart L, Terwindt GM, Boomsma DI, Rodriguez-Acevedo AJ, Nyholt DR. Genetic epidemiology of migraine and depression. Cephalalgia. 2016;36(7):679-691
DOI: 10.1177/0333102416638520

Yokoyama Y, Jelenkovic A, Sund R, Sung J, Hopper JL, Ooki S, Heikkilä K, Aaltonen S, Tarnoki AD, Tarnoki DL, Willemsen G, Bartels M, Beijsterveldt CEM van, Plomin R, Rebato E, Rose RJ, Goldberg JH, Rasmussen F, Hur YM, Sørensen TIA, Boomsma DI, Kaprio J, Silventoinen K, many others. Twin's Birth-Order Differences in Height and Body Mass Index From Birth to Old Age: A Pooled Study of 26 Twin Cohorts Participating in the CODATwins Project. Twin Research and Human Genetics. 2016;19(2):112-124
DOI: 10.1017/thg.2016.11

Zanoni P, Khetarpal SA, Larach DB, Hancock-Cerutti WF, Millar JS, Cuchel M, DerOhannessian S, Kontush A, Surendran P, Saleheen D, CHD Exome+ Consortium, CARDIoGRAM Exome Consortium, Global Lipids Genetics Consortium, Willemsen G, Boomsma DI, many others. Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease. Science. 2016;351(6278):1166-1171
DOI: 10.1126/science.aad3517
Supplementary Materials (zip file)

Zeeuw EL de, Beijsterveldt CEM van, Glasner TJ, Geus EJC de, Boomsma DI. Arithmetic, reading and writing performance has a strong genetic component: A study in primary school children. Learning and Individual Differences. 2016;47:156-166
DOI: 10.1016/j.lindif.2016.01.009

Zhao H, Eising E, Vries B de, Vijfhuizen LS, Anttila V, Winsvold BS, Kurth T, Stefansson H, Kallela M, Malik R, Ligthart L, Boomsma DI, Wessman M, Stefansson K, Chasman DI, Palotie A, Martin NG, Montgomery GW, Ferrari MD, Terwindt GM, Maagdenberg AMJM van den, Nyholt DR, others. Gene-based pleiotropy across migraine with aura and migraine without aura patient groups. Cephalalgia. 2016;36(7):648-657
DOI: 10.1177/0333102415591497
Supplementary Materials (zip file)

Zilhão NR, Smit DJA, Boomsma DI, Cath DC. Cross-Disorder Genetic Analysis of Tic Disorders, Obsessive–Compulsive, and Hoarding Symptoms. Frontiers in Psychiatry. 2016;7(120), Open
DOI: 10.3389/fpsyt.2016.00120