Publications in scientific journals: 2017

Research based on NTR data

2017

Begeer S, Ma Y, Koot HM, Wierda M, Beijsterveldt CEM van, Boomsma DI, Bartels M. Brief Report: Influence of gender and age on parent reported subjective well-being in children with and without autism. Research in Autism Spectrum Disorders. 2017;35:86-91
DOI: 10.1016/j.rasd.2016.11.004

Bigdeli TB, Ripke S, Peterson RE, Trzaskowski M, Bacanu SA, Abdellaoui A, Andlauer TFM, Beekman ATF, Berger K, Blackwood DHR, Boomsma DI, Geus EJC de, Hottenga JJ, Middeldorp CM, Milaneschi Y, Penninx BWJH, Peyrot WJ, Weissman MM, Wellmann J, Willemsen G, Witt SH, Levinson DF, Lewis CM, Wray NR, Flint J, Sullivan PF, Kendler KS, many others, on behalf of the CONVERGE consortium and and Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. Genetic effects influencing risk for major depressive disorder in China and Europe. Translational Psychiatry. 2017;7:e1074, Open
DOI: 10.1038/tp.2016.292
Supplementary Materials (zip file)

Bogl LH, Jelenkovic A, Vuoksimaa E, Ahrenfeldt L, Pietiläinen KH, Stazi MA, Fagnani C, D’Ippolito C, Hur YM, Jeong HU, Willemsen G, Bartels M, Beijsterveldt CEM van, Buchwald D, Tarnoki AD, Tarnoki DL, Yokoyama Y, Hopper JL, Loos RJF, Boomsma DI, Sørensen TIA, Silventoinen K, Kaprio J, many others. Does the sex of one’s co-twin affect height and BMI in adulthood? A study of dizygotic adult twins from 31 cohorts. Biology of Sex Differences. 2017;8(14):1-12
DOI: 10.1186/s13293-017-0134-x
Supplementary Materials (zip file)

Bolhuis K, Lubke GH, Ende J van der, Bartels M, Beijsterveldt CEM van, Lichtenstein P, Larsson H, Jaddoe VWV, Kushner SA, Verhulst FC, Boomsma DI, Tiemeier H. Disentangling Heterogeneity of Childhood Disruptive Behavior Problems Into Dimensions and Subgroups. Journal of the American Academy of Child & Adolescent Psychiatry. 2017;56(8):678-686
DOI: 10.1016/j.jaac.2017.05.019
Supplementary Materials (zip file)

Bonder MJ, Luijk R, Zhernakova DV, Moed M, Deelen P, Vermaat M, Iterson M van, Dijk F van, Galen M van, Bot J, Pool R, Dongen J van, Hottenga JJ, the BIOS Consortium, Slagboom PE, Wijmenga C, Veldink JH, Greevenbroek MMJ van, Duijn CM van, Boomsma DI, Isaacs A, Jansen R, Meurs JBJ van, Hoen PAC 't, Franke L, Heijmans BT, many others. Disease variants alter transcription factor levels and methylation of their binding sites. Nature Genetics. 2017;49(1):131-138
DOI: 10.1038/ng.3721
Supplementary Materials (zip file)

Bot M, Middeldorp CM, Geus EJC de, Lau HM, Sinke M, Nieuwenhuizen B van, Smit JH, Boomsma DI, Penninx BWJH. Validity of LIDAS (LIfetime Depression Assessment Self-report): a self-report online assessment of lifetime major depressive disorder. Psychological Medicine. 2017;47(2):279-289
DOI: 10.1017/S0033291716002312
Supplementary Materials (zip file)

Brouwer RM, Panizzon MS, Glahn DC, Hibar DP, Hua X, Jahanshad N, Abramovic L, Zubicaray GI de, Franz CE, Hansell NK, Hickie IB, Koenis MMG, Martin NG, Mather KA, McMahon KL, Schnack HG, Strike LT, Swagerman SC, Thalamuthu A, Wen W, Gilmore JH, Gogtay N, Kahn RS, Sachdev PS, Wright MJ, Boomsma DI, Kremen WS, Thompson PM, Hulshoff Pol HE. Genetic influences on individual differences in longitudinal changes in global and subcortical brain volumes: Results of the ENIGMA plasticity working group. Human Brain Mapping. 2017;38(9):4444-4458
DOI: 10.1002/hbm.23672
Supplementary Materials (zip file)

Cath DC, Nizar K, Boomsma DI, Mathews CA. Age-Specific Prevalence of Hoarding and Obsessive Compulsive Disorder: A Population-Based Study. The American Journal of Geriatric Psychiatry. 2017;25(3):245-255
DOI: 10.1016/j.jagp.2016.11.006

Day FR, Thompson DJ, Helgason H, Chasman DI, Finucane H, Sulem P, Ruth KS, Whalen S, Sarkar AK, Albrecht E, Hottenga JJ, Geus EJC de, Mbarek H, Willemsen G, Boomsma DI, The LifeLines Cohort study, The InterAct Consortium, kConFab/AOCS Investigators, Endometrial Cancer Association Consortium, Ovarian Cancer Association Consortium, PRACTICAL Consortium, Spurdle AB, Thorsteindottir U, Pollard KS, Easton DF, Tung JY, Chang-Claude J, Hinds D, Murray A, Murabito JM, Stefansson K, Ong KK, Perry JRB, many others. Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk. Nature Genetics. 2017;49(6):834-841
DOI: 10.1038/ng.3841
Supplementary Materials (zip file)

Demuru M, Gouw AA, Hillebrand A, Stam CJ, Dijk BW van, Scheltens P, Tijms BM, Konijnenberg E, Kate M ten, Braber A den, Smit DJA, Boomsma DI, Visser PJ. Functional and effective whole brain connectivity using magnetoencephalography to identify monozygotic twin pairs. Nature Scientific Reports. 2017;7(1):9685, Open
DOI: 10.1038/s41598-017-10235-y
Supplementary Materials (zip file)

Direk N, Williams S, Smith JA, Ripke S, Air T, Amare AT, Amin N, Baune BT, Bennett DA, Blackwood DHR, Boomsma DI, Geus EJC de, Hottenga JJ, Milaneschi Y, Montgomery GW, Penninx BWJH, Umbricht D, Auwera S van der, Ware EB, Weir DR, Weissman MM, Willemsen G, Yang J, Zhao W, Tiemeier H, Sullivan PF, many others. An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype. Biological Psychiatry. 2017;82(5):322-329
DOI: 10.1016/j.biopsych.2016.11.013
Supplementary Materials (zip file)

Doornweerd S, IJzerman RG, Weijs PJM, Diamant M, Geus EJC de, Boomsma DI. Lower birth weight is associated with alterations in dietary intake in adolescents independent of genetic factors: A twin study. Clinical Nutrition. 2017;36(1):179-185
DOI: 10.1016/j.clnu.2015.10.012

Doornweerd S, Duinkerken E van, Geus EJC de, Arbab-Zadeh P, Veltman DJ, IJzerman RG. Overweight is associated with lower resting state functional connectivity in females after eliminating genetic effects: A twin study. Human Brain Mapping. 2017;38(10):5069-5081
DOI: 10.1002/hbm.23715

Ehli EA, Abdellaoui A, Fedko IO, Grieser C, Nohzadeh-Malakshah S, Willemsen G, Geus EJC de, Boomsma DI, Davies GE, Hottenga JJ. A method to customize population-specific arrays for genome-wide association testing. European Journal of Human Genetics. 2017;25(2):267-270
DOI: 10.1038/ejhg.2016.152
Supplementary Materials (zip file)

Ent D van 't, Braber A den, Baselmans BML, Brouwer RM, Dolan CV, Hulshoff Pol HE, Geus EJC de, Bartels M. Associations between subjective well-being and subcortical brain volumes. Nature Scientific Reports. 2017;7(6957):1-11, Open
DOI: 10.1038/s41598-017-07120-z

Fedko IO, Wesseldijk LW, Nivard MG, Hottenga JJ, Beijsterveldt CEM van, Middeldorp CM, Bartels M, Boomsma DI. Heritability of Behavioral Problems in 7-Year Olds Based on Shared and Unique Aspects of Parental Views. Behavior Genetics, 47(2):152-163
DOI: 10.1007/s10519-016-9823-1
Supplementary Materials (zip file)

Ferreira MAR, Jansen R, Willemsen G, Penninx BWJH, Bain LM, Vicente CT, Revez JA, Matheson MC, Hui J, Tung JY, Baltic S, Souëf P Le, Montgomery GW, Martin NG, Robertson CF, James A, Thompson PJ, Boomsma DI, Hopper JL, Hinds DA, Werder RB, Phipps S, Australian Asthma Genetics Consortium Collaborators. Gene-based analysis of regulatory variants identifies 4 putative novel asthma risk genes related to nucleotide synthesis and signaling. Journal of Allergy and Clinical Immunology, 139(4):1148-1157
DOI: 10.1016/j.jaci.2016.07.017
Supplementary Materials (zip file)

Ferreira MAR, Vonk JM, Baurecht H, Marenholz I, Tian C, Hoffman JD, Helmer Q, Tillander A, Ullemar V, Dongen J van, Hottenga JJ, Willemsen G, 23andMe Research Team, AAGC Collaborators, BIOS Consortium, LifeLines Cohort Study, Weidinger S, Magnusson PKE, Jansen R, Jorgenson E, Lee YA, Boomsma DI, Almqvist C, Karlsson R, Koppelman GH, Paternoster L, many others. Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology. Nature Genetics. 2017;49(12):1752-1757
DOI: 10.1038/ng.3985
Supplementary Materials (zip file)

Finnicum CT, Dolan CV, Willemsen G, Weber ZM, Petersen JL, Beck JJ, Codd V, Boomsma DI, Davies GE, Ehli EA. Relative Telomere Repeat Mass in Buccal and Leukocyte-Derived DNA. PLOS ONE. 2017;12(1):e0170765
DOI: 10.1371/journal.pone.0170765

Francioli LC, Cretu-Stancu M, Garimella KV, Fromer M, Kloosterman WP, Genome of the Netherlands Consortium, Boomsma DI, Abdellaoui A, Hottenga JJ, Willemsen G, Samocha KE, Neale BM, Daly MJ, Banks E, DePristo MA, Bakker PIW de. A framework for the detection of de novo mutations in family-based sequencing data. European Journal of Human Genetics. 2017;25(2):227-233, Open
DOI: 10.1038/ejhg.2016.147
Supplementary Materials (zip file)

Graff M, Scott RA, Justice AE, Young KL, Feitosa MF, Barata L, Winkler TW, Chu AY, Mahajan A, Hadley D, Huppertz C, Willemsen G, Peyrot WJ, Hottenga JJ, Milaneschi Y, Montgomery GW, Moor MHM de, Snieder H, Penninx BWJH, Geus EJC de, Boomsma DI, CHARGE Consortium, EPIC-InterAct Consortium, PAGE Consortium, Liu CT, Hirschhorn JN, Klein RJ, Johnson AD, Borecki IB, Franks PW, North KE, Cupples LA, Loos RJF, Kilpeläinen TO, many others. Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. PLOS Genetics. 2017;13(4):e1006528
DOI: 10.1371/journal.pgen.1006528
Supplementary Materials (zip file)

Grootheest G van, Ariel A, Glasner TJ, Verkerk B, Beijsterveldt CEM van, Laan J van der, Groot M de, Visser S, Bakker B, Boomsma DI. Linkage of health insurance data to the Netherlands Twin Register. International Journal of Population Data Science. 2017;1(1):028
DOI: 10.23889/ijpds.v1i1.45

Hägg S, Zhan Y, Karlsson R, Gerritsen L, Ploner A, Lee SJ van der, Broer L, Deelen J, Marioni RE, Wong A, Lundquist A, Zhu G, Hansell NK, Sillanpää E, Fedko IO, Amin NA, Beekman M, Craen AJM de, Degerman S, Harris SE, Kan KJ, Martin-Ruiz CM, Montgomery GW, NeuroCHARGE Cognitive Working Group, Adolfsson AN, Reynolds CA, Samani NJ, Suchiman HED, Viljanen A, Zglinicki T von, Wright MJ, Hottenga JJ, Boomsma DI, Rantanen T, Kaprio JA, Nyholt DR, Martin NG, Nyberg L, Adolfsson R, Kuh D, Starr JM, Deary IJ, Slagboom PE, Duijn CM van, Codd V, Pedersen NL, ENGAGE Consortium. Short telomere length is associated with impaired cognitive performance in European ancestry cohorts. Translational Psychiatry. 2017;7:e1100, Open
DOI: 10.1038/tp.2017.73
Supplementary Materials (zip file)

Haller T, Leitsalu L, Fischer K, Nuotio ML, Esko T, Boomsma DI, Kyvik KO, Spector TD, Perola M, Metspalu A. MixFit: Methodology for Computing Ancestry-Related Genetic Scores at the Individual Level and Its Application to the Estonian and Finnish Population Studies. PLOS ONE. 2017;12(1):e0170325
DOI: 10.1371/journal.pone.0170325
Supplementary Materials (zip file)

Hibar DP, Adams HH, Jahanshad N, Chauhan G, Stein JL, Hofer E, Renteria ME, Bis JC, Arias-Vasquez A, Ikram MK, Braber A den, Boomsma DI, Geus EJC de, Fedko IO, Hottenga JJ, Penninx BWJH, Ent D van 't, Wright MJ, Longstreth WT, Schumann G, Grabe HJ, Franke B, Launer LJ, Medland SE, Seshadri S, Thompson PM, Arfan Ikram M, many others. Novel genetic loci associated with hippocampal volume. Nature Communications. 2017;8:13624, Open
DOI: 10.1038/ncomms13624
Supplementary Materials (zip file)

Hillger JM, Roy B le, Wang Z, Mulder-Krieger T, Boomsma DI, Slagboom PE, Danen EHJ, IJzerman AP, Heitman LH. Phenotypic screening of cannabinoid receptor 2 ligands shows different sensitivity to genotype. Biochemical Pharmacology. 2017;130:60-70
DOI: 10.1016/j.bcp.2017.01.014

Houtem CMHH van, Wijk AJ van, Boomsma DI, Ligthart L, Visscher CM, Jongh A de. The factor structure of dental fear. European Journal of Oral Sciences. 2017;125(3):195-201
DOI: 10.1111/eos.12343
Supplementary Materials (zip file)

Hu Y, Ehli EA, Boomsma DI. MicroRNAs as biomarkers for psychiatric disorders with a focus on autism spectrum disorder: Current progress in genetic association studies, expression profiling, and translational research. Autism Research. 2017;10(7):1184-1203
DOI: 10.1002/aur.1789
Supplementary Materials (zip file)

Huguet P, Carlier M, Dolan CV, Geus EJC de, Boomsma DI. Social Comparison Orientation in Monozygotic and Dizygotic Twins. Twin Research and Human Genetics. 2017;20(6):550-557
DOI: 10.1017/thg.2017.61

Huppertz C, Bartels M, Geus EJC de, Beijsterveldt CEM van, Rose RJ, Kaprio J, Silventoinen K. The effects of parental education on exercise behavior in childhood and youth: a study in Dutch and Finnish twins. Scandinavian Journal of Medicine & Science in Sports. 2017;27(10):1143-1156
DOI: 10.1111/sms.12727
Supplementary Materials (zip file)

Jansen R, Hottenga JJ, Nivard MG, Abdellaoui A, Laport B, Geus EJC de, Wright FA, Penninx BWJH, Boomsma DI. Conditional eQTL Analysis Reveals Allelic Heterogeneity of Gene Expression. Human Molecular Genetics. 2017;26(8):1444-1451
DOI: 10.1093/hmg/ddx043
Supplementary Materials (zip file)

Jelenkovic A, Yokoyama Y, Sund R, Pietiläinen KH, Hur YM, Willemsen G, Bartels M, Beijsterveldt CEM van, Ooki S, Saudino KJ, Plomin R, Ji F, Ning F, Pang Z, Rebato E, Krueger RF, McGue M, Pahlen S, Boomsma DI, Sørensen TIA, Kaprio J, Silventoinen K, many others. Association between birthweight and later body mass index: an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project. International Journal of Epidemiology. 2017;46(5):1488-1498
DOI: 10.1093/ije/dyx031
Supplementary Materials (zip file)

Jong PF de, Bergen E van. Issues in diagnosing dyslexia (book chapter). Developmental Perspectives in Written Language and Literacy: In honor of Ludo Verhoeven. 2017;349-361
DOI: 10.1075/z.206.21dej
https://benjamins.com/#catalog/books/z.206/main

Joshi PK, Pirastu N, Kentistou KA, Fischer K, Hofer E, Schraut KE, Clark DW, Nutile T, Barnes CLK, Timmers PRHJ, Abdellaoui A, Hottenga JJ, Ligthart L, Slagboom PE, Metspalu A, Boomsma DI, Hayward C, Chasman Dl, Martin NG, Sattar N, Campbell H, Esko T, Kutalik Z, Wilson JF. Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity. Nature Communications. 2017;8:910, Open
DOI: 10.1038/s41467-017-00934-5
Supplementary Materials (zip file)

Justice AE, Winkler TW, Feitosa MF, Graff M, Fisher VA, Young K, Barata L, Deng X, Czajkowski J, Hadley D, Vink JM, Geus EJC de, Hottenga JJ, Lubke G, Willemsen G, Boomsma DI, Duijn CM van, Heid IM, Mohlke KL, Marchini J, Loos RJF, Kilpeläinen TO, Liu CT, Borecki IB, North KE, Cupples LA, many others. Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. Nature Communications, 8:14977, Open
DOI: 10.1038/ncomms14977
Supplementary Materials (zip file)

Kittelsrud J, Ehli EA, Petersen V, Jung T, Willemsen G, Boomsma DI, Davies GE. Establishment of the Avera Twin Register in the Midwest USA. Twin Research and Human Genetics. 2017;20(5):414-418
DOI: 10.1017/thg.2017.45

Kluiver H de, Buizer-Voskamp JE, Dolan CV, Boomsma DI. Paternal age and psychiatric disorders: A review. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 2017;174(3):202-213
DOI: 10.1002/ajmg.b.32508
Supplementary Materials (zip file)

Lepik K, Annilo T, Kukuskina V, eQTLGen Consortium, Kisand K, Kutalik Z, Peterson P, Peterson H, Boomsma DI, Nivard MG, Dongen J van. C-reactive protein upregulates the whole blood expression of CD59 - an integrative analysis. PLOS Computational Biology. 2017;13(9):e1005766
DOI: 10.1371/journal.pcbi.1005766
Supplementary Materials (zip file)

Lin BD, Willemsen G, Fedko IO, Jansen R, Penninx BWJH, Geus EJC de, Kluft C, Hottenga JJ, Boomsma DI. Heritability and GWAS Studies for Monocyte–Lymphocyte Ratio. Twin Research and Human Genetics. 2017;20(2):97-107
DOI: 10.1017/thg.2017.3

Lin BD, Carnero-Montoro E, Bell JT, Boomsma DI, Geus EJC de, Jansen R, Kluft C, Mangino M, Penninx BWJH, Spector TD, Willemsen G, Hottenga JJ. 2SNP heritability and effects of genetic variants for neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio. Journal of Human Genetics. 2017;62:979-988
DOI: 10.1038/jhg.2017.76

Luningham JM, McArtor DB, Bartels M, Boomsma DI, Lubke GH. Sum Scores in Twin Growth Curve Models: Practicality Versus Bias. Behavior Genetics. 2017;47(5):516-536
DOI: 10.1007/s10519-017-9864-0

Maciejewski DF, Renteria ME, Abdellaoui A, Medland SE, Few LR, Gordon SD, Madden PAF, Montgomery GW, Trull TJ, Heath AC, Statham DJ, Martin NG, Zietsch BP, Verweij KJH. The Association of Genetic Predisposition to Depressive Symptoms with Non-suicidal and Suicidal Self-Injuries. Behavior Genetics. 2017;47(1):3-10
DOI: 10.1007/s10519-016-9809-z

Maes HH, Prom-Wormley E, Eaves LJ, Hyun Rhee S, Hewitt JK, Young S, Corley R, McGue M, Iacono WG, Legrand L, Samek DR, Murrelle EL, Silberg JL, Miles DR, Schieken RM, Beunen GP, Thomis M, Rose RJ, Dick DM, Boomsma DI, Bartels M, Vink JM, Lichtenstein P, White V, Kaprio J, Neale MC. A Genetic Epidemiological Mega Analysis of Smoking Initiation in Adolescents. Nicotine & Tobacco Research. 2017;19(4):401-409
DOI: 10.1093/ntr/ntw294
Supplementary Materials (zip file)

Mbarek H, Milaneschi Y, Hottenga JJ, Ligthart L, Geus EJC de, Ehli EA, Willemsen G, Davies GE, Smit JH, Boomsma DI, Penninx BWJH. Genome-Wide Significance for PCLO as a Gene for Major Depressive Disorder. Twin Research and Human Genetics. 2017;20(4):267-270
DOI: 10.1017/thg.2017.30
Supplementary Materials (zip file)

McArtor DB, Lin BD, Hottenga JJ, Boomsma DI, Willemsen G, Lubke GH. Using a multivariate model to assess the interactive effects of demographics and lifestyle on the hematological profile. Biomarkers in Medicine. 2017;11(6):427-438
DOI: 10.2217/bmm-2016-0285

Milaneschi Y, Lamers F, Peyrot WJ, Baune BT, Breen G, Dehghan A, Forstner AJ, Grabe HJ, Homuth G, Kan C, Lewis C, Mullins N, Nauck M, Pistis G, Preisig M, Rivera M, Rietschel M, Streit F, Strohmaier J, Teumer A, Auwera S van der, Wray NR, Boomsma DI, Penninx BWJH, CHARGE inflammation working group, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. Genetic Association of Major Depression With Atypical Features and Obesity-Related Immunometabolic Dysregulations. JAMA Psychiatry. 2017;74(12):1214-1225
DOI: 10.1001/jamapsychiatry.2017.3016
Supplementary Materials (zip file)

Minica CC, Mbarek H, Pool R, Dolan CV, Boomsma DI, Vink JM. Pathways to smoking behaviours: biological insights from the Tobacco and Genetics Consortium meta-analysis. Molecular Psychiatry. 2017;22(1):82-88
DOI: 10.1038/mp.2016.20
Supplementary Materials (zip file)

Neumann A, Direk N, Crawford AA, Mirza S, Adams H, Bolton J, Hayward C, Strachan DP, Payne EK, Smith JA, Milaneschi Y, Penninx BWJH, Hottenga JJ, Geus EJC de, Oldehinkel AJ, Most PJ van der, Rijke Y de, Walker BR, Tiemeier H. The low single nucleotide polymorphism heritability of plasma and saliva cortisol levels. Psychoneuroendocrinology. 2017;85:88-95
DOI: 10.1016/j.psyneuen.2017.08.011
Supplementary Materials (zip file)

Nivard MG, Gage SH, Hottenga JJ, Beijsterveldt CEM van, Abdellaoui A, Bartels M, Baselmans BML, Ligthart L, St Pourcain B, Boomsma DI, Munafò MR, Middeldorp CM. Genetic Overlap Between Schizophrenia and Developmental Psychopathology: Longitudinal and Multivariate Polygenic Risk Prediction of Common Psychiatric Traits During Development. Schizophrenia Bulletin. 2017;43(6):1197-1207
DOI: 10.1093/schbul/sbx031
Supplementary Materials (zip file)

Nivard MG, Lubke GH, Dolan CV, Evans DM, St. Pourcain B, Munafò MR, Middeldorp CM. Joint developmental trajectories of internalizing and externalizing disorders between childhood and adolescence. Development and Psychopathology. 2017;29(3):919-928
DOI: 10.1017/S0954579416000572

Nolte IM, Munoz ML, Tragante V, Amare AT, Jansen R, Vaez A, Heyde B von der, Avery CL, Bis JC, Dierckx B, Dongen J van, Nivard MG, Abdellaoui A, Boomsma DI, Hottenga JJ, Neijts M, Willemsen G, Penninx BWJH, Stricker BH, Tiemeier H, Vrijkotte TGM, Asselbergs FW, Brundel BJJM, Heckbert SR, Whitsel EA, Hoed M den, Snieder H, Geus EJC de, many others. Genetic loci associated with heart rate variability and their effects on cardiac disease risk. Nature Communications. 2017;8:15805, Open
DOI: 10.1038/ncomms15805
Supplementary Materials (zip file)

Power RA, Tansey KE, Nørmølle Buttenschøn H, Cohen-Woods S, Bigdeli T, Hall LS, Kutalik Z, Lee SH, Ripke S, Steinberg S, Boomsma DI, Hottenga JJ, Middeldorp CM, Milaneschi Y, Montgomery GW, Penninx BWJH, Smit JH, CONVERGE Consortium, CARDIoGRAM consortium, GERAD1 Consortium, Breen G, Lewis CM, many others. Genome-wide Association for Major Depression Through Age at Onset Stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. Biological Psychiatry. 2017;81(4):325-335
DOI: 10.1016/j.biopsych.2016.05.010
Supplementary Materials (zip file)

Richard MA, Huan T, Ligthart S, Gondalia R, Jhun MA, Brody JA, Irvin MR, Marioni R, Shen J, Tsai PC, BIOS Consortium, Boomsma DI, Pool R, Dongen J van, Hottenga JJ, Sotoodehnia N, Smith JA, Arnett DK, Deary IJ, Baccarelli AA, Bell JT, Whitsel E, Dehghan A, Levy D, Fornage M, many others. DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation. The American Journal of Human Genetics. 2017;101(6):888-902
DOI: 10.1016/j.ajhg.2017.09.028
Supplementary Materials (zip file)

Rietschel L, Streit F, Zhu G, McAloney K, Frank J, Couvy-Duchesne B, Witt SH, Binz TM, CORtisolNETwork (CORNET) Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (PGC), Abdellaoui A, Geus EJC de, Hottenga JJ, Mbarek H, Middeldorp CM, Willemsen G, Boomsma DI, Schulze TG, Wüst S, Nöthen MM, Baumgartner MR, Walker BR, Crawford AA, Colodro-Conde L, Medland SE, Martin NG, Rietschel M, others. Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes. Nature Scientific Reports. 2017;7(15351), Open
DOI: 10.1038/s41598-017-11852-3
Supplementary Materials (zip file)

Rivera M, Locke AE, Corre T, Czamara D, Wolf C, Ching-López A, Milaneschi Y, Kloiber S, Cohen-Woods S, Rucker J, Boomsma DI, Hottenga JJ, Penninx BWJH, Tozzi F, Uher R, Vollenweider P, Waeber G, Willemsen G, Craig IW, Farmer AE, Lewis CM, Breen G, McGuffin P, others. Interaction between the FTO gene, body mass index and depression: meta-analysis of 13701 individuals. British Journal of Psychiatry. 2017;211(2):70-76
DOI: 10.1192/bjp.bp.116.183475

Robinson MR, Kleinman A, Graff M, Vinkhuyzen AAE, Couper D, Miller MB, Peyrot WJ, Abdellaoui A, Zietsch BP, Nolte IM, Vliet-Ostaptchouk JV van, Snieder H, The LifeLines Cohort study, Genetic Investigation of Anthropometric Traits (GIANT) consortium, Medland SE, Martin NG, Magnusson PKE, Iacono WG, McGue M, North KE, Yang J, Visscher PM. Genetic evidence of assortative mating in humans. Nature Human Behaviour. 2017;1(0016)
DOI: 10.1038/s41562-016-0016
Supplementary Materials (zip file)

Roeling MP, Willemsen G, Boomsma DI. Heritability of Working in a Creative Profession. Behavior Genetics. 2017;47(3):298-304
DOI: 10.1007/s10519-016-9832-0

Schutte NM, Nederend I, Hudziak JJ, Bartels M, Geus EJC de. Heritability of the affective response to exercise and its correlation to exercise behavior. Psychology of Sport and Exercise. 2017;31:139-148
DOI: 10.1016/j.psychsport.2016.12.001

Schwabe I, Boomsma DI, Berg SM van den. Increased environmental sensitivity in high mathematics performance. Learning and Individual Differences. 2017;54
DOI: 10.1016/j.lindif.2017.01.018

Schwabe I, Boomsma DI, Berg SM van den. Mathematical Ability and Socio-Economic Background: IRT Modeling to Estimate Genotype by Environment Interaction. Twin Research and Human Genetics. 2017;20(6):511-520
DOI: 10.1017/thg.2017.59
Supplementary Materials (zip file)

Silventoinen K, Jelenkovic A, Sund R, Yokoyama Y, Hur YM, Cozen W, Hwang AE, Mack TM, Honda C, Inui F, Bartels M, Beijsterveldt CEM van, Willemsen G, Derom CA, Vlietinck RF, Loos RJF, Hopper JL, Sung J, Maes HH, Turkheimer E, Boomsma DI, Sørensen TIA, Kaprio J, many others. Differences in genetic and environmental variation in adult body mass index by sex, age, time period, and region: an individual-based pooled analysis of 40 twin cohorts. The American Journal of Clinical Nutrition. 2017;106(2):457-466
DOI: 10.3945/ajcn.117.153643
Supplementary Materials (zip file)

Silventoinen K, Jelenkovic A, Latvala A, Sund R, Yokoyama Y, Ullemar V, Almqvist C, Derom CA, Vlietinck RF, Loos RJF, Willemsen G, Bartels M, Beijsterveldt CEM van, Tarnoki DL, Franz E, Kremen WS, Lyons MJ, Maia JA, Freitas DL, Turkheimer E, Sørensen TIA, Boomsma DI, Kaprio J, many others. Education in Twins and Their Parents Across Birth Cohorts Over 100 years: An Individual-Level Pooled Analysis of 42-Twin Cohorts. Twin Research and Human Genetics. 2017;20(5):395-405
DOI: 10.1017/thg.2017.49
Supplementary Materials (zip file)

Slof-Op 't Landt MCT, Furth EF van, Beijsterveldt CEM van, Bartels M, Willemsen G, Geus EJC de, Ligthart L, Boomsma DI. Prevalence of dieting and fear of weight gain across ages: a community sample from adolescents to the elderly. International Journal of Public Health. 2017;62(8):911-919
DOI: 10.1007/s00038-017-0948-7
Supplementary Materials (zip file)

Smit DJA, Anokhin AP. Development and genetics of brain temporal stability related to attention problems in adolescent twins. International Journal of Psychophysiology. 2017;115:86-97
DOI: 10.1016/j.ijpsycho.2016.07.498

Sohail M, Vakhrusheva OA, Hoon Sul J, Pulit SL, Francioli LC, Genome of the Netherlands Consortium, Abdellaoui A, Hottenga JJ, Willemsen G, Boomsma DI, Alzheimer’s Disease Neuroimaging Initiative, Berg LH van den, Veldink JH, Bakker PIW de, Bazykin GA, Kondrashov AS, Sunyaev SR, many others. Negative selection in humans and fruit flies involves synergistic epistasis. Science. 2017;356(6337):539-542
DOI: 10.1126/science.aah5238

Swagerman SC, Bergen E van, Dolan CV, Geus EJC de, Koenis MMG, Hulshoff Pol HE, Boomsma DI. Genetic transmission of reading ability. Brain and Language. 2017;172:3-8
DOI: 10.1016/j.bandl.2015.07.008

Treur JL, Taylor AE, Ware JJ, Nivard MG, Neale MC, McMahon G, Hottenga JJ, Baselmans BML, Boomsma DI, Munafò MR, Vink JM. Smoking and caffeine consumption: a genetic analysis of their association. Addiction Biology. 2017;22(4):1090-1102
DOI: 10.1111/adb.12391
Supplementary Materials (zip file)

Veldkamp SAM, Bergen E van, Zeeuw EL de, Beijsterveldt CEM van, Boomsma DI, Bartels M. Bullying and Victimization: The Effect of Close Companionship. Twin Research and Human Genetics. 2017;20(1):19-27
DOI: 10.1017/thg.2016.99

Verduijn J, Milaneschi Y, Peyrot WJ, Hottenga JJ, Abdellaoui A, Geus EJC de, Smit JH, Breen G, Lewis CM, Boomsma DI, Beekman ATF, Penninx BWJH. Using Clinical Characteristics to Identify Which Patients With Major Depressive Disorder Have a Higher Genetic Load for Three Psychiatric Disorders. Biological Psychiatry. 2017;81(4):316-324
DOI: 10.1016/j.biopsych.2016.05.024
Supplementary Materials (zip file)

Verweij KJH, Abdellaoui A, Nivard MG, Sainz Cort A, Ligthart L, Draisma HHM, Minica CC, Gillespie NA, Willemsen G, Hottenga JJ, Boomsma DI, Vink JM. Genetic association between schizophrenia and cannabis use. Drug and Alcohol Dependence. 2017;171:117-121
DOI: 10.1016/j.drugalcdep.2016.09.022

Verweij KJH, Treur JL, Vreeker A, Brunt TM, Willemsen G, Boomsma DI, Vink JM. Heritability of lifetime ecstasy use. Drug and Alcohol Dependence. 2017;178:66-69
DOI: 10.1016/j.drugalcdep.2017.05.007
Supplementary Materials (zip file)

Vink JM, Jansen R, Brooks A, Willemsen G, Grootheest G van, Geus EJC de, Smit JH, Penninx BWJH, Boomsma DI. Differential gene expression patterns between smokers and non-smokers: cause or consequence? Addiction Biology, 22(2):550-560
DOI: 10.1111/adb.12322
Supplementary Materials (zip file)

Vries PS de, Sabater-Lleal M, Chasman DI, Trompet S, Ahluwalia TS, Teumer A, Kleber ME, Chen MH, Wang JJ, Attia JR, Pool R, Hottenga JJ, Draisma HHM, Slagboom PE, Uitterlinden AG, Geus EJC de, Boomsma DI, Watkins H, Tang W, Ridker PM, Jukema JW, Scott RJ, Mitchell P, Hansen T, O'Donnell CJ, Smith NL, Strachan DP, Dehghan A, many others. Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study. PLOS ONE. 2017;12(1):e0167742
DOI: 10.1371/journal.pone.0167742
Supplementary Materials (zip file)

Wain LV, Vaez A, Jansen R, Joehanes R, Most PJ van der, Mesut Erzurumluoglu A, O’Reilly PF, Cabrera CP, Warren HR, Rose LM, Hottenga JJ, Geus EJC de, Penninx BWJH, Willemsen G, Boomsma DI, Elliott P, Chasman DI, Chakravarti A, Knight J, Morris AP, Levy D, Tobin MD, Snieder H, Caulfield MJ, Ehret GB, many others. Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney. Hypertension. 2017;70:e4-e19
DOI: 10.1161/HYPERTENSIONAHA.117.09438
Supplementary Materials (zip file)

Warren HR, Evangelou E, Cabrera CP, Gao H, Ren M, Mifsud B, Ntalla I, Surendran P, Liu C, Cook JP, Hottenga JJ, Geus EJC de, Willemsen G, Boomsma DI, The International Consortium of Blood Pressure (ICBP) 1000G Analyses, The CHD Exome+ Consortium, The ExomeBP Consortium, The T2D-GENES Consortium, The GoT2DGenes Consortium, The Cohorts for Heart and Ageing Research in Genome Epidemiology (CHARGE) BP Exome Consortium, The International Genomics of Blood Pressure (iGEN-BP) Consortium, Barnes MR, Tzoulaki I, Caulfield MJ, Elliott P, The UK Biobank CardioMetabolic Consortium BP working group. Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. Nature Genetics. 2017;49(3):403-415
DOI: 10.1038/ng.3768
Supplementary Materials (zip file)

Wesseldijk LW, Fedko IO, Bartels M, Nivard MG, Beijsterveldt CEM van, Boomsma DI, Middeldorp CM. Psychopathology in 7-year-old children: Differences in maternal and paternal ratings and the genetic epidemiology. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 2017;174(3):251-260
DOI: 10.1002/ajmg.b.32500
Supplementary Materials (zip file)

Wheeler E, Leong A, Liu CT, Hivert MF, Strawbridge RJ, Podmore C, Li M, Yao J, Sim X, Hong J, Hottenga JJ, Willemsen G, EPIC-CVD Consortium, EPIC-InterAct Consortium, LifeLines Cohort Study, Boomsma DI, Geus EJC de, Florez JC, Sladek R, Dupuis J, Morris AP, Tai ES, Selvin E, Rotter JI, Langenberg C, Barroso I, Meigs JB. Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis. PLOS Medicine. 2017;14(9):e1002383
DOI: 10.1371/journal.pmed.1002383
Supplementary Materials (zip file)

Witt SH, Streit F, Jungkunz M, Frank J, Awasthi S, Reinbold CS, Treutlein J, Degenhardt F, Forstner AJ, Heilmann-Heimbach S, Abdellaoui A, Boomsma DI, Geus EJC de, Hottenga JJ, Middeldorp CM, Milaneschi Y, Penninx BWJH, Willemsen G, Bipolar Disorders Working Group of the Psychiatric Genomics Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Cichon S, Nöthen MM, Ripke S, Mobascher A, Rujescu D, Lieb K, Roepke S, Schmahl C, Bohus M, Rietschel M, many others. Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia. Translational Psychiatry. 2017;7(e1155)
DOI: 10.1038/tp.2017.115
Supplementary Materials (zip file)

Wood AR, Jonsson A, Jackson AU, Wang N, Leewen N van, Palmer ND, Kobes S, Deelen J, Boquete-Vilarino L, Paananen J, Boomsma DI, Geus EJC de, Eekhoff EMW, Fritsche A, Kramer M, Nijpels G, Simonis-Bik A, Smith U, Wagenknecht LE, Baier L, Bowden DW, Hansen T, Walker M, Watanabe RM, Hart LM 't, Hanson RL, Frayling TM, many others. A Genome-Wide Association Study of IVGTT-Based Measures of First Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants. Diabetes. 2017;66(8):2296-2309
DOI: 10.2337/db16-1452

Zeeuw EL de, Beijsterveldt CEM van, Ehli EA, Geus EJC de, Boomsma DI. Attention Deficit Hyperactivity Disorder Symptoms and Low Educational Achievement: Evidence Supporting A Causal Hypothesis. Behavior Genetics. 2017;47(3):278-289
DOI: 10.1007/s10519-017-9836-4
Supplementary Materials (zip file)

Zeeuw EL de, Beijsterveldt CEM van, Hoekstra RA, Bartels M, Boomsma DI. The etiology of autistic traits in preschoolers: a population-based twin study. Journal of Child Psychology and Psychiatry. 2017;58(8):893-901
DOI: 10.1111/jcpp.12741

Zeeuw EL de, Boomsma DI. Country-by-genotype-by-environment interaction in childhood academic achievement. Proceedings of the National Academy of Sciences. 2017;114(51):13318-13320
DOI: 10.1073/pnas.1718938115

Zhernakova DV, Deelen P, Vermaat M, Iterson M van, Galen M van, Arindrarto W, Hof P van 't, Mei H, Dijk F van, Westra HJ, Pool R, Dongen J van, Hottenga JJ, Boomsma DI, Duijn CM van, Wijmenga C, Slagboom PE, Swertz MA, Isaacs A, Meurs JBJ van, Jansen R, Heijmans BT, Hoen PAC 't, Franke L. Identification of context-dependent expression quantitative trait loci in whole blood. Nature Genetics. 2017;49(1):139-145
DOI: 10.1038/ng.3737

Zilhão NR, Olthof MC, Smit DJA, Cath DC, Ligthart L, Mathews CA, Delucchi K, Boomsma DI, Dolan CV. Heritability of tic disorders: a twin-family study. Psychological Medicine. 2017;47(6):1085-1096
DOI: 10.1017/S0033291716002981
Supplementary Materials (zip file)