Publications in scientific journals: 2018

Research based on NTR data

2018

Abdellaoui A, Nivard MG, Hottenga JJ, Fedko IO, Verweij KJH, Baselmans BML, Ehli EA, Davies GE, Bartels M, Boomsma DI, Cacioppo JT. Predicting Loneliness with Polygenic Scores of Social, Psychological, and Psychiatric Traits. Genes, Brain and Behavior. 2018;17(6):e12472
DOI: 10.1111/gbb.12472

Auwera S van der, Peyrot WJ, Milaneschi Y, Hertel J, Baune B, Breen G, Byrne E, Dunn EC, Fisher H, Homuth G, Levinson D, Lewis C, Mills N, Mullins N, Nauck M, Pistis G, Preisig M, Rietschel M, Ripke S, Sullivan P Teumer A, Völzke H, Boomsma DI, Wray NR, Penninx B, Grabe H & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. Genome-wide gene-environment interaction in depression: A systematic evaluation of candidate genes. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 2018;177(1):40-49
DOI: 10.1002/ajmg.b.32593
Supplementary Materials (zip file)

Bartels M, Hendriks A, Mauri M, Krapohl E, Whipp A, Bolhuis K, Colodro Conde L, Luningham J, Ip HF, Hagenbeek F, Roetman P, Gatej R, Lamers A, Nivard MG, Dongen J van, Lu Y, Middeldorp CM, Beijsterveldt CEM van, Vermeiren R, Hankemeijer T, Kluft C, Medland SE, Lundström S, Rose R, Pulkkinen L, Vuoksimaa E, Korhonen T, Martin NG, Lubke G, Finkenauer C, Fanos V, Tiemeier H, Lichtenstein P, Plomin R, Kaprio J, Boomsma DI. Childhood aggression and the co-occurrence of behavioural and emotional problems: results across ages 3–16 years from multiple raters in six cohorts in the EU-ACTION project. European Child & Adolescent Psychiatry. 2018;27(9):1105-1121
DOI: 10.1007/s00787-018-1169-1

Baselmans BML, Willems YE, Beijsterveldt CEM van, Ligthart L, Willemsen G, Dolan CV, Boomsma DI, Bartels M. Unraveling the Genetic and Environmental Relationship Between Well-Being and Depressive Symptoms Throughout the Lifespan. Frontiers in Psychiatry. 2018;9:261
DOI: 10.3389/fpsyt.2018.00261
Supplementary Materials (zip file)

Baselmans BML, Bartels M. A genetic perspective on the relationship between eudaimonic -and hedonic well-being. Nature Scientific Reports. 2018;8(1):14610
DOI: 10.1038/s41598-018-32638-1
Supplementary Materials (zip file)

Beaumont RN, Warrington NM, Cavadino A, Tyrrell J, Nodzenski M, Horikoshi M, Geller F, Myhre R, Richmond RC, Paternoster L, Hottenga JJ, Early Growth Genetics (EGG) Consortium, Willemsen G, Bartels M, Boomsma DI, Hayes G, Frayling TM, Hivert MF, Felix JF, Hyppönen E, Lowe Jr WL, Evans DM, Lawlor DA, Feenstra B, Freathy RM. Genome-wide association study of offspring birth weight in 86,577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics. Human Molecular Genetics. 2018;27(4):742-756
DOI: 10.1093/hmg/ddx429
Supplementary Materials (zip file)

Bergen E van, Snowling MJ, Zeeuw EL de, Beijsterveldt CEM van, Dolan CV, Boomsma DI. Why do children read more? The influence of reading ability on voluntary reading practices. Journal of Child Psychology and Psychiatry. 2018;59(11):1205-1214
DOI: 10.1111/jcpp.12910
Supplementary Materials (zip file)

Boomsma DI, Helmer Q, Nieuwboer HA, Hottenga JJ, Moor MHM de, Berg SM van den, Davies GE, Vink JM, Schouten MJ, Dolan CV, Willemsen G, Bartels M, Beijsterveldt CEM van, Ligthart L, Geus EJC de. An Extended Twin-Pedigree Study of Neuroticism in the Netherlands Twin Register. Behavior Genetics. 2018;48(1):1-11
DOI: 10.1007/s10519-017-9872-0

The Brainstorm Consortium, Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, Escott-Price V, Falcone GJ, Gormley P, Malik R, Ligthart L, Hottenga JJ, Penninx BWJH, Boomsma DI, Posthuma D, Middeldorp CM, Jansen R, Geus EJC de, Cath DC, Derks EM, Sklar P, Williams J, Wood NW, Cotsapas C, Palotie A, Smoller JW, Sullivan P, Rosand J, Corvin A, Neale BM, many others. Analysis of shared heritability in common disorders of the brain. Science. 2018;360(6395):eaap8757
DOI: 10.1126/science.aap8757
Supplementary Materials (zip file)

Colodro-Conde L, Couvy-Duchesne B, Whitfield JB, Streit F, Gordon S, Kemper KE, Yengo L, Zheng Z, Trzaskowski M, Zeeuw EL de, Nivard MG, Das M, Neale RE, Macgregor S, Olsen CM, Whiteman DC, Boomsma DI, Yang J, Rietschel M, McGrath JJ, Medland SE, Martin NG. Association Between Population Density and Genetic Risk for Schizophrenia. JAMA Psychiatry. 2018;75(9):901-910
DOI: 10.1001/jamapsychiatry.2018.1581

Culverhouse RC, Saccone NL, Horton AC, Ma Y, Anstey KJ, Banaschewski T, Burmeister M, Cohen-Woods S, Etain B, Fisher HL, Middeldorp CM, Hottenga JJ, Peyrot WJ, Auwera S van der, Willemsen G, Boomsma DI, Geus EJC de, Penninx BWJH, Serretti A, Smit JH, Stefanis NC, Surtees PG, Völzke H, Weinstein M, Whooley M, Nurnberger Jr JI, Breslau N, Bierut LJ, many others. Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression. Molecular Psychiatry. 2018;23(1):133-142
DOI: 10.1038/mp.2017.44

Demenais F, Margaritte-Jeannin P, Barnes KC, Cookson WOC, Altmüller J, Ang W, Barr RG, Beaty TH, Becker AB, Beilby J, Boomsma DI, Australian Asthma Genetics Consortium Collaborators, Hottenga JJ, Mbarek H, Willemsen G, Williams LK, Wouters IM, Yang JJ, Zhao JH, Moffatt MF, Ober C, Nicolae DL, many others. Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. Nature Genetics. 2018;50(1):42-53
DOI: 10.1038/s41588-017-0014-7
Supplementary Materials (zip file)

Dongen J van, BIOS Consortium, Bonder MJ, Dekkers KF, Nivard MG, Iterson M van, Willemsen G, Beekman M, Spek A van der, Meurs JBJ van, Franke L, Heijmans BT, Duijn CM van, Slagboom PE, Boomsma DI. DNA methylation signatures of educational attainment. npj Science of Learning. 2018;3(7):1-14, Open
DOI: 10.1038/s41539-018-0020-2
Supplementary Materials (zip file)

Dongen J van, Ehli EA, Jansen R, Beijsterveldt CEM van, Willemsen G, Hottenga JJ, Kallsen NA, Peyton SA, Breeze CE, Kluft C, Heijmans BT, Bartels M, Davies GE, Boomsma DI. Genome-wide analysis of DNA methylation in buccal cells: a study of monozygotic twins and mQTLs. Epigenetics & Chromatin. 2018;11(54)
DOI: 10.1186/s13072-018-0225-x

Doornweerd S, Geus EJC de, Barkhof F, Bloemendaal L van, Boomsma DI, Dongen J van, Drent ML, Willemsen G, Veltman DJ, IJzerman RG. Brain reward responses to food stimuli among female monozygotic twins discordant for BMI. Brain Imaging and Behavior. 2018;12(3):718-727
DOI: 10.1007/s11682-017-9711-1
Supplementary Materials (zip file)

Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N, Cabrera CP, Karaman I, Boomsma DI, Geus EJC de, Hottenga JJ, Willemsen G, Metspalu A, Hung AM, O’Donnell CJ, Edwards TL, Psaty BM, Tzoulaki I, Barnes MR, Wain LV, Elliott P, Caulfield MJ, many others. Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nature Genetics. 2018;50(10):1412-1425
DOI: 10.1038/s41588-018-0205-x
Supplementary Materials (zip file)

Finnicum CT, Doornweerd S, Dolan CV, Luningham JM, Beck JJ, Willemsen G, Ehli EA, Boomsma DI, IJzerman RG, Davies GE, Geus EJC de. Metataxonomic Analysis of Individuals at BMI Extremes and Monozygotic Twins Discordant for BMI. Twin Research and Human Genetics. 2018;21(3):203-213
DOI: 10.1017/thg.2018.26
Supplementary Materials (zip file)

Gormley P, Kurki MI, Hiekkala ME, Veerapen K, Häppölä P, Mitchell AA, Lal D, Palta P, Surakka I, Kaunisto MA, 23andMe Research Team, International Headache Genetics Consortium (IHGC), Boomsma DI, Ligthart L, Posthuma D, Runz H, Daly MJ, Neale BM, Ripatti S, Kallela M, Wessman M, Palotie A, many others. Common Variant Burden Contributes to the Familial Aggregation of Migraine in 1,589 Families. Neuron. 2018;98(4):743-753
DOI: 10.1016/j.neuron.2018.04.014
Supplementary Materials (zip file)

Gudmundsdottir V, Krogh Pedersen H, Allebrandt KV, Brorsson C, Leeuwen N van, Banasik K, Mahajan A, Groves CJ, Bunt M van de, Dawed AY, Fritsche A, Staiger H, Simonis-Bik AMC, Deelen J, Kramer MHH, Dietrich A, Hübschle T, Willemsen G, Häring HU, Geus EJC de, Boomsma DI, Eekhoff EMW, Ferrer J, McCarthy MI, Pearson ER, Gupta R, Brunak S, Hart LM 't. Integrative network analysis highlights biological processes underlying GLP-1 stimulated insulin secretion: A DIRECT study. PLOS ONE. 2018;13(1):e0189886
DOI: 10.1371/journal.pone.0189886
Supplementary Materials (zip file)

Hagenbeek FA, Dongen J van, Kluft C, Hankemeier T, Ligthart L, Willemsen G, Geus EJC de, Vink JM, Bartels M, Boomsma DI. Adult aggressive behavior in humans and biomarkers: a focus on lipids and methylation. Journal of Pediatric and Neonatal Individualized Medicine. 2018;7(2):e070204
DOI: 10.7363/070204
Supplementary Materials (zip file)

Hancock DB, Guo Y, Reginsson GW, Gaddis NC, Lutz SM, Sherva R, Loukola A, Minica CC, Markunas CA, Han Y, Young KA, Gudbjartsson DF, Gu F, McNeil DW, Qaiser B, Glasheen C, Olson S, Landi MT, Madden PAF, Farrer LA, Vink J, Saccone NL, Neale MC, Kranzler R, McKay J, Hung RJ, Amos CI, Marazita ML, Boomsma DI, Baker TB, Gelernter J, Kaprio J, Caporaso NE, Thorgeirsson TE, Hokanson JE, Bierut LJ, Stefansson K, Johnson EO. Genome-wide association study across European and African American ancestries identifies a SNP in DNMT3B contributing to nicotine dependence. Molecular Psychiatry. 2018;23(9):1-9
DOI: 10.1038/mp.2017.193
Supplementary Materials (zip file)

Hart LM 't, Vogelzangs N, Mook-Kanamori DO, Brahimaj A, Nano J, Heijden AAWA van der, Willems van Dijk K, Slieker RC, Steyerberg E, Arfan Ikram M, Beekman M, Boomsma DI, Duijn CM van, Slagboom PE, Stehouwer CDA, Schalkwijk CG, Arts ICW, Dekker JM, Dehghan A, Muka T, Kallen CJH van der, Nijpels G, Greevenbroek M van. Blood metabolomic measures associate with present and future glycemic control in type 2 diabetes. Journal of Clinical Endocrinology & Metabolism. 2018;103(12):4569-4579
DOI: 10.1210/jc.2018-01165
Supplementary Materials (zip file)

Heikkilä K, Beijsterveldt CEM van, Haukka J, Iivanainen M, Saari-Kemppainen A, Silventoinen K, Boomsma DI, Yokoyama Y, Vuoksimaa E. Triplets, birthweight, and handedness. PNAS. 2018;115(23):6076-6081
DOI: 10.1073/pnas.1719567115
Supplementary Materials (zip file)

Hysi PG, Valdes AM, Liu F, Furlotte NA, Evans DM, Bataille V, Visconti A, Hemani G, McMahon G, Ring SM, Lin BD, Willemsen G, Hottenga JJ, Hamer MA, Duijn CM van, Nijsten T, Mackey DA, Falchi M, Boomsma DI, Martin NG, Hinds DA, Kayser M, Spector TD, The International Visible Trait Genetics Consortium. Genome-wide association meta-analysis of individuals of European ancestry identifies new loci explaining a substantial fraction of hair color variation and heritability. Nature Genetics. 2018;50(5):652-656
DOI: 10.1038/s41588-018-0100-5
Supplementary Materials (zip file)

Ip HF, Jansen R, Abdellaoui A, Bartels M, UK Brain Expression Consortium, Boomsma DI, Nivard MG. Characterizing the Relation Between Expression QTLs and Complex Traits: Exploring the Role of Tissue Specificity. Behavior Genetics. 2018;48(5):374-385
DOI: 10.1007/s10519-018-9914-2
Supplementary Materials (zip file)

Jelenkovic A, Yokoyama Y, Sund R, Hur YM, Harris JR, Brandt I, Sevenius Nilsen T, Ooki S, Ullemar V, Almqvist C, Willemsen G, Bartels M, Beijsterveldt CEM van, Tarnoki DL, Kim J, Lee J, Lee S, Sung J, Loos RJF, Boomsma DI, Sørensen TIA, Kaprio J, Silventoinen K, many others. Associations between birth size and later height from infancy through adulthood: An individual based pooled analysis of 28 twin cohorts participating in the CODATwins project. Early Human Development. 2018;120:53-60
DOI: 10.1016/j.earlhumdev.2018.04.004
Supplementary Materials (zip file)

Jelenkovic A, Sund R, Yokoyama Y, Hur YM, Ullemar V, Almqvist C, Magnusson PKE, Willemsen G, Bartels M, Beijsterveldt CEM van, Plomin R, Abramson L, Burt SA, Klump KL, Vlietinck RF, Derom CA, Loos RJF, Boomsma DI, Sørensen TIA, Kaprio J, Silventoinen K, many others. Birth size and gestational age in opposite-sex twins as compared to same-sex twins: An individual-based pooled analysis of 21 cohorts. Nature Scientific Reports. 2018;8, Open
DOI: 10.1038/s41598-018-24634-2

Jong S de, Abdalla Diniz MJ, Saloma A, Gadelha A, Santoro ML, Ota VK, Noto C, Major Depressive Disorder and Bipolar Disorder Working Groups of the Psychiatric Genomics Consortium, Abdellaoui A, Derks EM, Dolan CV, Hottenga JJ, Mbarek H, Middeldorp CM, Nivard MG, Willemsen G, Boomsma DI, Geus EJC de, Penninx BWJH, Curtis C, Newhouse SJ, Patel H, Hall LS, O'Reilly PF, Belangero SI, Bressan RA, Breen G. Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder. Communications Biology. 2018;1(163):1-10
DOI: 10.1038/s42003-018-0155-y
Supplementary Materials (zip file)

Kate M ten, Sudre CH, Braber A den, Konijnenberg E, Nivard MG, Cardoso MJ, Scheltens P, Ourselin S, Boomsma DI, Barkhof F, Visser PJ. White matter hyperintensities and vascular risk factors in monozygotic twins. Neurobiology of Aging. 2018;66:40-48
DOI: 10.1016/j.neurobiolaging.2018.02.002
Supplementary Materials (zip file)

Koenis MMG, Brouwer RM, Swagerman SC, Soelen ILC van, Boomsma DI, Hulshoff Pol HE. Association between structural brain network efficiency and intelligence increases during adolescence. Human Brain Mapping. 2018;39(2):822-836
DOI: 10.1002/hbm.23885
Supplementary Materials (zip file)

Konijnenberg E, Carter SF, Kate M ten, Braber A den, Tomassen J, Amadi C, Wesselman L, Nguyen HT, Kreeke JA van de, Yaqub M, Demuru M, Mulder SD, Hillebrand A, Bouwman FH, Teunissen CE, Serné EH, Moll AC, Verbraak FD, Hinz R, Pendleton N, Lammertsma AA, Berckel BNM van, Barkhof F, Boomsma DI, Scheltens P, Herholz K, Visser PJ. The EMIF-AD PreclinAD study: study design and baseline cohort overview. Alzheimer's Research & Therapy. 2018;10(75)
DOI: 10.1186/s13195-018-0406-7

Korpela K, Costea P, Coelho LP, Kandels-Lewis S, Willemsen G, Boomsma DI, Segata N, Bork P. Selective maternal seeding and environment shape the human gut microbiome. Genome Research. 2018;28(4):561-568
DOI: 10.1101/gr.233940.117
Supplementary Materials (zip file)

Kreeke JA van de, Nguyen HT, Konijnenberg E, Tomassen J, Braber A den, Kate M ten, Sudre CH, Barkhof F, Boomsma DI, Tan HS, Verbraak FD, Visser PJ. Retinal and Cerebral Microvasculopathy: Relationships and Their Genetic Contributions. Investigative Ophthalmology & Visual Science. 2018;59(12):5025-5031
DOI: 10.1167/iovs.18-25341
Supplementary Materials (zip file)

Lee JJ, Wedow R, Okbay A, Kong E, Maghzian O, Zacher M, Anh Nguyen-Viet T, Bowers P, Sidorenko J, Karlsson Linnér R, 23andMe Research Team, COGENT (Cognitive Genomics Consortium), Social Science Genetic Association Consortium, Abdellaoui A, Peyrot WJ, Hottenga JJ, LifeLines Cohort Study, Vinkhuyzen AAE, Willemsen G, Boomsma DI, Duijn CM van, Penninx BWJH, Posthuma D, Uitterlinden AG, Chabris CF, Meyer MN, Laibson DI, Yang, J Johannesson M, Koellinger PD, Turley P, Visscher PM, Benjamin DJ, Cesarini D, many others. Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. Nature Genetics. 2018;50(8):1112-1121
DOI: 10.1038/s41588-018-0147-3
Supplementary Materials (zip file)

Ligthart L, Huijgen A, Willemsen G, Geus EJC de, Boomsma DI. Are Migraine and Tension-Type Headache Genetically Related? An Investigation of Twin Family Data. Twin Research and Human Genetics. 2018;21(2):112-118
DOI: 10.1017/thg.2018.5

Ligthart S, Vaez A, Võsa U, Stathopoulou MG, Vries PS de, Prins BP, Most PJ van der, Tanaka T, Naderi E, Rose LM, Pool R, LifeLines Cohort Study, CHARGE inflammation working group, Draisma HHM, Hottenga JJ, Willemsen G, Geus EJC de, Beekman M, Boomsma DI, Penninx BWJH, Slagboom PE, Gross M, Bis JC, Franke L, Franco OH, Benjamin EJ, Chasman DI, Dupuis J, Snieder H, Dehghan A, Alizadeh BZ, many others. Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders. The American Journal of Human Genetics. 2018;103(5):691-706
DOI: 10.1016/j.ajhg.2018.09.009
Supplementary Materials (zip file)

Lubke GH, McArtor DB, Boomsma DI, Bartels M. Genetic and Environmental Contributions to the Development of Childhood Aggression. Developmental Psychology. 2018;54(1):39-50
DOI: 10.1037/dev0000403

Luijk R, Dekkers KF, Iterson M, Arindrarto W, Claringbould A, Hop P, BIOS Consortium, Boomsma DI, Duijn CM van, Greevenbroek MMJ van, Veldink JH, Wijmenga C, Franke L, Hoen PAC ’t, Jansen R, Meurs J van, Mei H, Slagboom PE, Heijmans BT, Zwet EW van. Genome-wide identification of directed gene networks using large-scale population genomics data. Nature Communications. 2018;9(1):3097, Open
DOI: 10.1038/s41467-018-05452-6
Supplementary Materials (zip file)

Luijk R, Wu H, Ward-Caviness CK, Hannon E, Carnero-Montoro E, Min JL, Mandaviya P, Müller-Nurasyid M, Mei H, Maarel SM van der, BIOS Consortium, Relton C, Mill J, Waldenberger M, Bell JT, Jansen R, Zhernakova A, Franke L, Hoen PAC ‘t, Boomsma DI, Duijn CM van, Greevenbroek MMJ van, Veldink JH, Wijmenga C, Meurs J van, Daxinger L, Slagboom PE, Zwet EW van, Dongen J van, Hottenga JJ, Pool R, Heijmans BT, many others. Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation. Nature Communications. 2018;9(3738), Open
DOI: 10.1038/s41467-018-05714-3
Supplementary Materials (zip file)

Mee DJ van der, Fedko IO, Hottenga JJ, Ehli EA, Zee MD van der, Ligthart L, Beijsterveldt CEM van, Davies GE, Bartels M, Landers JG, Geus EJC de. Dopaminergic Genetic Variants and Voluntary Externally Paced Exercise Behavior. Medicine & Science in Sports & Exercise. 2018;50(4):700-708
DOI: 10.1249/MSS.0000000000001479

Mies GW, Verweij KJH, Treur JL, Ligthart L, Fedko IO, Hottenga JJ, Willemsen G, Bartels M, Boomsma DI, Vink JM. Polygenic risk for alcohol consumption and its association with alcohol-related phenotypes: Do stress and life satisfaction moderate these relationships? Drug and Alcohol Dependence. 2018;183:7-12
DOI: 10.1016/j.drugalcdep.2017.10.018

Minica CC, Dolan CV, Boomsma DI, Geus EJC de, Neale MC. Extending Causality Tests with Genetic Instruments: An Integration of Mendelian Randomization with the Classical Twin Design. Behavior Genetics. 2018;48(4):337-349
DOI: 10.1007/s10519-018-9904-4
Supplementary Materials (zip file)

Minica CC, Verweij KJH, Most PJ van der, Mbarek H, Bernard M, Eijk KR van, Lind PA, Liu MZ, Maciejewski DF, Palviainen T, Abdellaoui A, Davies GE, Ehli EA, Fedko IO, Hottenga JJ, Neale MC, Loukola A, Boks MP, Snieder H, Munafò MR, Gelernter J, Boomsma DI, Martin NG, Gillespie NA, Vink JM, Derks EM, many others. Genome-Wide Association Meta-Analysis of Age at First Cannabis Use. Addiction. 2018;113(11):2073-2086
DOI: 10.1111/add.14368
Supplementary Materials (zip file)

Molnos S, Wahl S, Haid M, Marelise E, Eekhoff W, Pool R, Floegel A, Deelen J, Much D, Draisma HHM, Simonis-Bik AMC, Willemsen G, Geus EJC de, Boomsma DI, Slagboom PE, Hummel S, Beekman M, Grallert H, Brunak S, McCarthy MI, Gupta R, Pearson ER, Adamski J, Hart LM ’t, many others. Metabolite ratios as potential biomarkers for type 2 diabetes: a DIRECT study. Diabetologia. 2018;61(1):117-129
DOI: 10.1007/s00125-017-4436-7
Supplementary Materials (zip file)

Odintsova VV, Willemsen G, Dolan CV, Hottenga JJ, Martin NG, Slagboom PE, Ordonana JR, Boomsma DI. Establishing a Twin Register: An Invaluable Resource for (Behavior) Genetic, Epidemiological, Biomarker, and 'Omics' Studies. Twin Research and Human Genetics. 2018;21(3):239-252
DOI: 10.1017/thg.2018.23

Ouwens KG, Jansen R, Tolhuis B, Slagboom PE, Penninx BWJH, Boomsma DI. A characterization of post-zygotic mutations identified in monozygotic twins. Human Mutation. 2018;39(10):1393-1401
DOI: 10.1002/humu.23586
Supplementary Materials (zip file)

Parmar P, Lowry E, Cugliari G, Suderman M, Wilson R, Karhunen V, Andrewi T, Wiklund P, Wielscher M, Guarrera S, Boomsma DI, Slagboom PE, Heijmans BT, BIOS Consortium, Rathmann W, Relton CL, Matullo G, Brenner H, Verweij N, Li S, Chambers JC, Järvelin MR, Sebert S, GLOBAL Meth QTL, many others. Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults. EBioMedicine, 38:206-216
DOI: 10.1016/j.ebiom.2018.10.066
Supplementary Materials (zip file)

Pasman JA, Verweij KJH, Gerring Z, Stringer S, Sanchez-Roige S, Treur JL, Abdellaoui A, Nivard MG, Baselmans BML, Ong JS, Ip HF, Zee MD van der, Bartels M, the 23andMe Research Team, The Substance Use Disorders Working Group of the Psychiatric Genomics Consortium, International Cannabis Consortium, Boomsma DI, Martin NG, Macgregor S, Perry JRB, Palmer AA, Posthuma D, Munafò MR, Gillespie NA, Derks EM, Vink JM, many others. GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia. Nature Neuroscience. 2018;21(9):1161-1170
DOI: 10.1038/s41593-018-0206-1
Supplementary Materials (zip file)

Peyrot WJ, Auwera S van der, Milaneschi Y, Dolan CV, Madden PAF, Sullivan PF, Strohmaier J, Ripke S, Rietschel M, Nivard MG, Mullins N, Montgomery GW, Henders AK, Heath AC, Fisher HL, Dunn EC, Byrne EM, Air TA, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Baune BT, Breen G, Levinson DF, Lewis CM, Martin NG, Nelson EN, Boomsma DI, Grabe HJ, Wray NR, Penninx BWJH. Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium. Biological Psychiatry. 2018;84(2):138-147
DOI: 10.1016/j.biopsych.2017.09.009
Supplementary Materials (zip file)

Piirtola M, Jelenkovic A, Latvala A, Sund R, Honda C, Inui F, Watanabe M, Tomizawa R, Iwatani Y, Ordonana JR, Derom CA, Vlietinck RF, Loos RJF, Silberg JL, Maes HH, Boomsma DI, Sørensen TIA, Korhonen T, Kaprio J, Silventoinen K, many others. Association of current and former smoking with body mass index: A study of smoking discordant twin pairs from 21 twin cohorts. PLOS One. 2018;13(7)
DOI: 10.1371/journal.pone.0200140
Supplementary Materials (zip file)

Qi T, Wu Y, Zeng J, Zhang F, Xue A, Jiang L, Zhu Z, Kemper K, Yengo L, Zheng Z, eQTLGen Consortium, Boomsma DI, Nivard MG, Penninx BWJH, Dongen J van, Marioni RE, Montgomery GW, Deary IJ, Wray NR, Visscher PM, McRae AF, Yang J , many others. Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood. Nature Communications. 2018;9:2282, Open
DOI: 10.1038/s41467-018-04558-1
Supplementary Materials (zip file)

Sandanger TM, Nøst TH, Guida F, Rylander C, Campanella G, Muller DC, Dongen J van, Boomsma DI, Johansson M, Vineis P, Vermeulen R, Lund E, Chadea M. DNA methylation and associated gene expression in blood prior to lung cancer diagnosis in the Norwegian Women and Cancer cohort. Scientific Reports. 2018;8(1):16714, Open
DOI: 10.1038/s41598-018-34334-6
Supplementary Materials (zip file)

Smit DJA, Wright MJ, Meyers JL, Martin NG, Ho YYW, Malone SM, Zhang J, Burwell SJ, Chorlian DB, Geus EJC de, Denys D, Hansell NK, Hottenga JJ, McGue M, Beijsterveldt CEM van, Jahanshad N, Thompson PM, Whelan CD, Medland SE, Porjesz B, Lacono WG, Boomsma DI. Genome-wide association analysis links multiple psychiatric liability genes to oscillatory brain activity. Human Brain Mapping. 2018;39(11):4183-4195
DOI: 10.1002/hbm.24238
Supplementary Materials (zip file)

Timmermans EJ, Lakerveld J, Beulens JWJ, Boomsma DI, Kramer SE, Oosterman M, Willemsen G, Stam M, Nijpels G, Schuengel C, Smit JH, Brunekreef B, Dekkers JEC, Deeg DJH, Penninx BWJH, Huisman M. Cohort profile: the Geoscience and Health Cohort Consortium (GECCO) in the Netherlands. BMJ Open. 2018;8:e021597
DOI: 10.1136/bmjopen-2018-021597

Treur JL, Verweij KJH, Abdellaoui A, Fedko IO, Zeeuw EL de, Ehli EA, Davies GE, Hottenga JJ, Willemsen G, Boomsma DI, Vink JM. Testing familial transmission of smoking with two different research designs. Nicotine and Tobacco Research. 2018;20(7):836-842
DOI: 10.1093/ntr/ntx121
Supplementary Materials (zip file)

Visscher CM, Schouten MJ, Ligthart L, Houtem CM van, Jongh A de, Boomsma DI. Shared Genetics of Temporomandibular Disorder Pain and Neck Pain: Results of a Twin Study. Journal of Oral & Facial Pain & Headache. 2018;32(2):107-112
DOI: 10.11607/ofph.2016

Waage J, Standl M, Curtin JA, Jessen LE, Thorsen J, Tian C, Schoettler N, the 23andMe Research Team, AAGC Collaborators, Flores C, Abdellaoui A, Beijsterveldt CEM van, Boomsma DI, Weidinger S, Weiss S, Willemsen G, Williams LK, Ober C, Hinds DA, Ferreira MA, Bisgaard H, Strachan DP, Bønnelykke K, many others. Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis. Nature Genetics. 2018;50(8):1072-1080
DOI: 10.1038/s41588-018-0157-1
Supplementary Materials (zip file)

Walters RK, Polimanti R, Johnson EC, McClintick JN, Adams MJ, Adkins AE, Aliev F, Bacanu SA, Batzler A, Bertelsen S, Hottenga JJ, Ligthart L, Mbarek H, Milaneschi Y, 23andMe Research Team, Boomsma DI, Penninx BWJH, Tarter RE, Vanyukov MM, Vrieze S, Wall TL, Whitfield JB, Zhao H, Neale BM, Gelernter J, Edenberg HJ, Agrawal A, many others. Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders. Nature Neuroscience. 2018;21(12):1656-1669
DOI: 10.1038/s41593-018-0275-1
Supplementary Materials (zip file)

Wang J, Kurilshikov A, Radjabzadeh D, Turpin W, Croitoru K, Bonder MJ, Jackson MA, Medina-Gomez C, Frost F, Homuth G, Rühlemann M, Hughes D, Kim H, MiBioGen Consortium Initiative, Boomsma DI, Davies GE, Geus EJC de, Ehli EA, Finnicum CT, IJzerman R, Mbarek H, Willemsen G, Spector TD, Bell JT, Steves CJ, Timpson N, Franke A, Wijmenga C, Meyer K, Kacprowski T, Franke L, Paterson AD, Raes J, Kraaij R, Zhernakova A, many others. Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative. Microbiome. 2018;6(1):101
DOI: 10.1186/s40168-018-0479-3
Supplementary Materials (zip file)

Ward-Caviness CK, Huffman JE, Evertt K, Germain M, Dongen J van, Hill WD, Jhun MA, Brody JA, Ghanbari M, Boomsma DI, Willemsen G, Ligthart L, Johnson AD, Gagnon F, Morange PE, Geus EJC de, Starr JM, Smith JA, Dehghan A, Björck HM, Smith NL, Peters A, many others. DNA methylation age is associated with an altered hemostatic profile in a multi-ethnic meta-analysis. Blood. 2018;132(17):1842-1850
DOI: 10.1182/blood-2018-02-831347
Supplementary Materials (zip file)

Warrier V, Grasby KL, Uzefovsky F, Toro R, Smith P, Chakrabarti B, Khadake J, Mawbey-Adamson E, Litterman N, Hottenga JJ, Lubke G, Boomsma DI, Martin NG, Hatemi PK, Medland SE, Hinds DA, Bourgeron T, Baron-Cohen S. Genome-wide meta-analysis of cognitive empathy: heritability, and correlates with sex, neuropsychiatric conditions and cognition. Molecular Psychiatry. 2018;23(6):1402-1409, Open
DOI: 10.1038/mp.2017.122
Supplementary Materials (zip file)

Wesseldijk LW, Dieleman GC, Steensel FJA van, Bleijenberg EJ, Bartels M, Bögels SM, Middeldorp CM. Do Parental Psychiatric Symptoms Predict Outcome in Children With Psychiatric Disorders? A Naturalistic Clinical Study. Journal of the American Academy of Child & Adolescent Psychiatry. 2018;57(9):669-677
DOI: 10.1016/j.jaac.2018.05.017

Wesseldijk LW, Bartels M, Vink JM, Beijsterveldt CEM van, Ligthart L, Boomsma DI, Middeldorp CM. Genetic and environmental influences on conduct and antisocial personality problems in childhood, adolescence, and adulthood. European Child & Adolescent Psychiatry. 2018;27(9):1123-1132
DOI: 10.1007/s00787-017-1014-y
Supplementary Materials (zip file)

Wesseldijk LW, Dieleman GC, Steensel FJA van, Bartels M, Hudziak JJ, Lindauer RJL, Bögels SM, Middeldorp CM. Risk factors for parental psychopathology: a study in families with children or adolescents with psychopathology. European Child & Adolescent Psychiatry. 2018;27(12):1575-1584
DOI: 10.1007/s00787-018-1156-6
Supplementary Materials (zip file)

Willems YE, Dolan CV, Beijsterveldt CEM van, Zeeuw EL de, Boomsma DI, Bartels M, Finkenauer C. Genetic and Environmental Influences on Self-Control: Assessing Self-Control with the ASEBA Self-Control Scale. Behavior Genetics. 2018;48(2):135-146
DOI: 10.1007/s10519-018-9887-1
Supplementary Materials (zip file)

Willems YE, Li JB, Hendriks AM, Bartels M, Finkenauer C. The Relationship between Family Violence and Self-Control in Adolescence: A Multi-Level Meta-Analysis. International Journal of Environmental Research and Public Health. 2018;15(11):2468
DOI: 10.3390/ijerph15112468

Wray NR, Ripke S, Mattheisen M, Trzaskowski M, Byrne EM, Abdellaoui A, Adams MJ, Agerbo E, Air TM, Andlauer TMF, Derks EM, Dolan CV, Hottenga JJ, Mbarek H, Middeldorp CM, Nivard MG, Posthuma D, Willemsen G, Boomsma DI, Geus EJC de, Penninx BWJH, Tiemeier H, Uher R, Völzke H, Weissman MM, Werge T, Winslow AR, Lewis CM, Levinson DF, Breen G, Børglum AD, Sullivan PF, The Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, many others. Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nature Genetics. 2018;50(5):668-681
DOI: 10.1038/s41588-018-0090-3
Supplementary Materials (zip file)

Xue A, Wu Y, Zhu Z, Zhang F, Kemper KE, Zheng Z, Yengo L, Lloyd-Jones LR, Sidorenko J, Wu Y, eQTLGen Consortium, Boomsma DI, Jansen R, Nivard MG, Penninx BWJH, Dongen J van, McRae AF, Visscher PM, Zeng J, Yang J, many others. Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes. Nature Communications. 2018;9(1):2941, Open
DOI: 10.1038/s41467-018-04951-w
Supplementary Materials (zip file)

Yang Y, Zhao H, Boomsma DI, Ligthart L, Belin AC, Davey Smith G, Esko T, Folkmann Hansen T, Freilinger TM, Arfan Ikram M, Kallela M, Kubisch C, Paraskevi C, Strachan DP, Wessman M, The International Headache Genetics Consortium, Maagdenberg AMJM van den, Hottenga JJ, Penninx BWJH, Terwindt GM, Nyholt DR. Molecular genetic overlap between migraine and major depressive disorder. European Journal of Human Genetics. 2018;26(8):1202-1216
DOI: 10.1038/s41431-018-0150-2
Supplementary Materials (zip file)

Yokoyama Y, Jelenkovic A, Hur YM, Sund R, Fagnani C, Stazi MA, Brescianini S, Ji F, Ning F, Pang Z, Bartels M, Beijsterveldt CEM van, Willemsen G, Tynelius P, Tarnoki AD, Tarnoki DL, Ooki S, Rose RJ, Pietiläinen KH, Sørensen TIA, Boomsma DI, Kaprio J, Silventoinen K, many others. Genetic and environmental factors affecting birth size variation: a pooled individual-based analysis of secular trends and global geographical differences using 26 twin cohorts. International Journal of Epidemiology. 2018;47(4):1195-1206
DOI: 10.1093/ije/dyy081
Supplementary Materials (zip file)

Yousefi S, Abbassi-Daloii T, Kraaijenbrink T, Vermaat M, Mei H, 't Hof P van, Iterson M van, Zhernakova DV, Claringbould A, Franke L, 't Hart LM, Slieker RC, Heijden A van der, Knijff P de, BIOS Consortium, Boomsma DI, Dongen J van, Hottenga JJ, Pool R, Hoen PAC 't. A SNP panel for identification of DNA and RNA specimens. BMC Genomics. 2018;19(90)
DOI: 10.1186/s12864-018-4482-7
Supplementary Materials (zip file)

Zilhão NR, Abdellaoui A, Smit DJA, Cath DC, Hottenga JJ, Boomsma DI. Polygenic prediction of obsessive compulsive symptoms. Molecular Psychiatry. 2018;23(2):168-169
DOI: 10.1038/mp.2017.248