GPC
The Genetics of Personality ConsortiumThe Genetics of Personality Consortium (GPC) is a large collaboration of genome-wide association studies for personality. The aim of the GPC is to detect genetic variants associated with personality traits, and to further our understanding of the molecular genetic basis of personality traits.
Big Five personality traits
In the first phase of the project, we conducted a meta-analysis of Genome-Wide Association Studies (GWAS) in 10 discovery cohorts (N=17375) and 5 replication cohorts (N=3294) for each of the Big Five personality traits as assessed with the NEO-Five Factor Inventory (Neuroticism, Extraversion, Openness to Experience, Agreeableness and Conscientiousness). HAPMAP build 36 release 22 was used as a reference panel to impute missing genotypes in cohorts. Results of the meta-analysis are available under GPC-1. Please carefully read the ReadmeGPC-1.pdf file when downloading the data. If data end up in a scientific publication (e.g. scientific article, presentation at meeting), please make sure you cite the appropriate publications (see under References).
Harmonized Neuroticism and Extraversion
In the second phase of the project, we conducted a meta-analysis of GWAS in 29 discovery cohorts (N=63661) and 1 replication cohort (N=9786) for two harmonized personality traits: Neuroticism and Extraversion. Personality item data from 9 different inventories were harmonized by applying Item Response Theory (IRT). This was followed by a meta-analysis of GWAS results for the harmonized Neuroticism and Extraversion scores. 1000G build 37 phase 1 v3 was used as a reference panel to impute missing genotypes in cohorts. Results of the meta-analysis are available under GPC-2. Please carefully read the ReadmeGPC-2.pdf file when downloading the data. If data end up in a scientific publication (e.g. scientific article, presentation at meeting), please make sure you cite the appropriate publications (see under References).
Contact
If you have questions, please contact:
| Project | Phenotypes | File with full meta-analysis results | References |
| GPC-1 | Neuroticism (NEO-FFI) | GPC-1.BigFiveNEO.zip | De Moor et al. (2012). Meta-analysis of genome-wide association studies for personality. Molecular Psychiatry, 17, 337-349 |
| Extraversion(NEO-FFI) | |||
| Openness to Experience (NEO-FFI) | |||
| Agreeableness (NEO-FFI) | |||
| Conscientiousness (NEO-FFI) | |||
| GPC-2 | Neuroticism (IRT) | GPC-2.NEUROTICISM.zip | De Moor, Van den Berg et al. (2015). Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association with Major Depressive Disorder. JAMA Psychiatry, 72(7):642-650 |
| Van den Berg, De Moor et al. (2014). Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory. Behavior Genetics, 44(4), 295-313 | |||
| - | Extraversion (IRT) | GPC-2.EXTRAVERSION.zip | Van den Berg, De Moor et al. (2016). Meta-analysis of genome-wide association studies for extraversion: Findings from the Genetics of Personality Consortium. Behavior Genetics, 46(2):170-182 |
| Van den Berg, De Moor et al. (2014). Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory. Behavior Genetics, 44(4), 295-313 |