Publications in scientific journals: 2012

Research based on NTR data


Aa N van der, Bartels M, Velde SJ te, Boomsma DI, Geus EJC de, Brug J. Genetic and Environmental Influences on Individual Differences in Sedentary Behavior During Adolescence. Archives of Pediatrics & Adolescent Medicine. 2012;166(6):509-514, Open Access
DOI: 10.1001/archpediatrics.2011.1658
Supplementary Materials (zip file)

Abdellaoui A, Moor MHM de, Geels LM, Beek JHDA van, Willemsen G, Boomsma DI. Thought Problems from Adolescence to Adulthood: Measurement Invariance and Longitudinal Heritability. Behavior Genetics. 2012;42(1):19-29, Open Access
DOI: 10.1007/s10519-011-9478-x
Supplementary Materials (zip file)

Althoff RR, Hudziak JJ, Willemsen G, Hudziak V, Bartels M, Boomsma DI. Genetic and Environmental Contributions to Self-Reported Thoughts of Self-Harm and Suicide. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 2012;159B(1):120-127
DOI: 10.1002/ajmg.b.32010

Amin N, Byrne E, Johnson J, Chenevix-Trench G, Walter S, Nolte IM, Vink JM, Rawal R, Mangino M, Teumer A, Hottenga JJ, Tiemeier H, Wolfenbuttel BHR, Oostra BA, Heath AC, Wichmann E, Spector TD, Grabe HJ, Boomsma DI, Martin NG, Duijn CM van, others. Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM. Molecular Psychiatry. 2012;17(11):1116-1129, Open Access
DOI: 10.1038/mp.2011.101
Supplementary Materials (zip file)

Arfan Ikram M, Fornage M, Smith AV, Seshadri S, Schmidt R, Debette S, Vrooman HA, Sigurdsson S, Ropele S, Taal HR, Mook-Kanamori DO, Coker LH, Longstreth Jr WT, Niessen WJ, Beijsterveldt CEM van, Groen-Blokhuis M, Hottenga JJ, Middeldorp CM, Nivard M, Willemsen G, Boomsma DI, others. Common variants at 6q22 and 17q21 are associated with intracranial volume. Nature Genetics. 2012;44(5):539-544
DOI: 10.1038/ng.2245
Supplementary Materials (zip file)

Bartels M, Weegen FI van, Beijsterveldt CEM van, Carlier M, Polderman TJC, Hoekstra RA, Boomsma DI. The five factor model of personality and intelligence: A twin study on the relationship between the two constructs. Personality and Individual Differences. 2012;53(4):368-373
DOI: 10.1016/j.paid.2012.02.007

Bartels M, Moor MHM de, Aa N van der, Boomsma DI, Geus EJC de. Regular exercise, subjective wellbeing, and internalizing problems in adolescence: causality or genetic pleiotropy? Frontiers in Genetics: Behavioral and Psychiatric Genetics. 2012;3(Article 4):1-12, Open Access
DOI: 10.3389/fgene.2012.00004

Beek JHDA van, Kendler KS, Moor MHM de, Geels LM, Bartels M, Vink JM, Berg SM van den, Willemsen G, Boomsma DI. Stable Genetic Effects on Symptoms of Alcohol Abuse and Dependence from Adolescence into Early Adulthood. Behavior Genetics. 2012;42(1):40-56, Open Access
DOI: 10.1007/s10519-011-9488-8

Boomsma DI. Similarities Despite Separation - Book Review. Science. 2012;337:157
DOI: 10.1126/science.1226444

Boraska V, Jeroncic A, Colonna V, Southam L, Nyholt DR, Rayner NW, Perry JRB, Toniolo D, Albrecht E, Ang W, Boomsma DI, Hottenga JJ, Montgomery GW, Vink JM, Willemsen G, Geus EJC de, Martin NG, Penninx BWJH, Ulivi S, Harst P van der, Vollenweider P, Völzke H, Wareham NJ, Wichmann H-E, Wilson JF, Rudan I, Xue Y, Zeggini E, others. Genome-wide meta-analysis of common variant differences between men and women. Human Molecular Genetics. 2012;21(21):4805-4815, Open Access
DOI: 10.1093/hmg/dds304
Supplementary Materials (zip file)

Braber A den, ‘t Ent D van, Cath DC, Veltman DJ, Boomsma DI, Geus EJC de. Brain Activation During Response Interference in Twins Discordant or Concordant for Obsessive Compulsive Symptoms. Twin Research and Human Genetics. 2012;15(Special Issue 3):372-383
DOI: 10.1017/thg.2012.2

Bradfield JP, Taal HR, Timpson NJ, Scherag A, Lecoeur C, Warrington NM, Hypponen E, Holst C, Valcarcel B, Thiering E, Boomsma DI, Farooqi IS, McCarthy MI, Froguel P, Meyre D, Hebebrand J, Jarvelin M-R, Jaddoe VWV, Davey Smith G, Hakonarson H, Grant SFA, many others. A genome-wide association meta-analysis identifies new childhood obesity loci. Nature Genetics. 2012;44(5):526-532
DOI: 10.1038/ng.2247
Supplementary Materials (zip file)

Brandsma M, Baas F, Bakker PIW de, Beem EP, Boomsma DI, Bovenberg J, Bueno-de-Mesquita B, Duijn C.M. van, Kiemeney LA, Klungel O, Leeuw PW de, Leeuwen FE van, Ridder-Numan J, Stolk RP, Slagboom PE, Swertz M, Wijmenga C, Ommen GJB van. How to kickstart a national biobanking infrastructure - experiences and prospects of BBMRI-NL. Norsk Epidemiologi. 2012;21(2):143-148

Brandys MK, Slof-Op’t Landt MCT, Elburg AA van, Ophoff R, Verduijn W, Meulenbelt I, Middeldorp CM, Boomsma DI, Furth EF van, Slagboom PE, Kas MJH, Adan RAH. Anorexia nervosa and the Val158Met polymorphism of the COMT gene: meta-analysis and new data. Psychiatric Genetics. 2012;22(3):130-136
DOI: 10.1097/YPG.0b013e328351859e

Brouwer RM, Mandl RCW, Schnack HG, Soelen ILC van, Baal GCM van, Peper JS, Kahn RS, Boomsma DI, Hulshoff Pol HE. White Matter Development in Early Puberty: A Longitudinal Volumetric and Diffusion Tensor Imaging Twin Study. PLOS ONE. 2012;7(4):e32316, Open Access
DOI: 10.1371/journal.pone.0032316

Dastani Z, Hivert M-F, Timpson N, Perry JRB, Yuan X, Scott RA, Henneman P, Heid IM, Kizer JR, Lyytikäinen L-P, Hottenga JJ, Geus EJC de, Willemsen G, Boomsma DI, others. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLOS Genetics. 2012;8(3):e1002607
DOI: 10.1371/journal.pgen.1002607

Distel MA, Roeling MP, Tielbeek JJ, Toor D van, Derom CA, Trull TJ, Boomsma DI. The Covariation of Trait Anger and Borderline Personality: A Bivariate Twin-Siblings Study. Journal of Abnormal Psychology. 2012;121(2):458-466
DOI: 10.1037/a0026393

Distel MA, Trull TJ, Moor MHM de, Vink JM, Geels LM, Beek JHDA van, Bartels M, Willemsen G, Thiery E, Derom CA, Neale MC, Boomsma DI. Borderline Personality Traits and Substance Use: Genetic Factors Underlie the Association with Smoking and Ever Use of Cannabis, but Not with High Alcohol Consumption. Journal of Personality Disorders. 2012;26(6):867-879
DOI: 10.1521/pedi.2012.26.6.867

Dongen J van, Slagboom PE, Draisma HHM, Martin NG, Boomsma DI. The continuing value of twin studies in the omics era. Nature Reviews Genetics. 2012;13(9):640-653
DOI: 10.1038/nrg3243
Supplementary Materials (zip file)

Ehli EA, Abdellaoui A, Hu Y, Hottenga JJ, Kattenberg M, Beijsterveldt CEM van, Bartels M, Althoff RR, Xiao X, Scheet P, Geus EJC de, Hudziak JJ, Boomsma DI, Davies GE. De novo and inherited CNVs in MZ twin pairs selected for discordance and concordance on Attention Problems. European Journal of Human Genetics. 2012;20(10):1037-1043, Open Access
DOI: 10.1038/ejhg.2012.49
Supplementary Materials (zip file)

Forsberg LA, Rasi C, Razzaghian HR, Pakalapati G, Waite L, Stanton Thilbeault K, Ronowicz A, Wineinger NE, Tiwari HK, Boomsma DI, O’Hanlon TP, Rider LG, Miller FW, Giedraitis V, Lannfelt L, Ingelsson M, Piotrowski A, Pedersen NL, Absher D, Dumanski JP, others. Age-Related Somatic Structural Changes in the Nuclear Genome of Human Blood Cells. The American Journal of Human Genetics. 2012;90(2):217-228, Open Archive
DOI: 10.1016/j.ajhg.2011.12.009
Supplementary Materials (zip file)

Fox CS, Liu Y, White CC, Feitosa M, Smith AV, Heard-Costa N, Lohman K, Hottenga JJ, Geus EJC de, Willemsen G, Boomsma DI, Garcia M, Eiriksdottir G, Carr JJ, Gudnason V, Harris TB, Cupples LA, Borecki IB. Genome-Wide Association for Abdominal Subcutaneous and Visceral Adipose Reveals a Novel Locus for Visceral Fat in Women. PLOS Genetics. 2012;8(5):e1002695, Open Access
DOI: 10.1371/journal.pgen.1002695
Supplementary Materials (zip file)

Geels LM, Bartels M, Beijsterveldt CEM van, Willemsen G, Aa N van der, Boomsma DI, Vink JM. Trends in adolescent alcohol use: Effects of age, sex and cohort on prevalence and heritability. Addiction. 2012;107(3):518-527
DOI: 10.1111/j.1360-0443.2011.03612.x
Supplementary Materials (zip file)

Geels LM, Groen-Blokhuis MM, Beijsterveldt CEM van, Vink JM, Middeldorp CM, Bartels M, Nelson KA, Huizenga PE, Davies GE, Boomsma DI. Maternal prenatal smoking and offspring emotional problems: No moderating effect of maternal or child 5-HTTLPR genotype. American Journal of Medical Genetics Part B. Neuropsychiatric Genetics. 2012;159B(8):1009-1012
DOI: 10.1002/ajmg.b.32110

Haren NEM van, Rijsdijk F, Schnack HG, Picchioni MM, Toulopoulou T, Weisbrod M, Sauer H, Erp TG van, Cannon TD, Huttunen MO, Boomsma DI, Hulshoff Pol HE, Murray RM, Kahn RS. The Genetic and Environmental Determinants of the Association Between Brain Abnormalities and Schizophrenia: The Schizophrenia Twins and Relatives Consortium. Biological Psychiatry. 2012;71(10):915-921, Open Access
DOI: 10.1016/j.biopsych.2012.01.010
Supplementary Materials (zip file)

Harst P van der, Zhang W, Mateo Leach I, Rendon A, Verweij N, Hottenga JJ, Abdellaoui A, Geus EJC de, Moor MHM de, Penninx BWJH, Willemsen G, Boomsma DI, Gieger C, Kooner JS, Ouwehand WH, Soranzo N, Chambers JC, others. Seventy-five genetic loci influencing the human red blood cell. Nature. 2012;492(7429):369-375
DOI: 10.1038/nature11677
Supplementary Materials (zip file)

Hartz SM, Short SE, Saccone NL, Culverhouse R, Chen L, Schwantes-An TH, Coon H, Han Y, Stephens SH, Sun J, Hottenga JJ, Willemsen G, Boomsma DI, Heath AC, Johnson EO, Kaprio J, Madden PAF, Martin NG, Stevens VL, Stitzel JA, Weiss RB, Kraft P, Bierut LJ, many others. Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers. Archives of General Psychiatry. 2012;69(8):854-860, Open Access
DOI: 10.1001/archgenpsychiatry.2012.124

Hulshoff Pol HE, Baal GCM van, Schnack HG, Brans RGH, Schot AC van der, Brouwer RM, Haren NEM van, Lepage C, Collins DL, Evans AC, Boomsma DI, Nolen W, Kahn RS. Overlapping and Segregating Structural Brain Abnormalities in Twins With Schizophrenia or Bipolar Disorder. Archives of General Psychiatry. 2012;69(4):349-359, Open Access
DOI: 10.1001/archgenpsychiatry.2011.1615
Supplementary Materials (zip file)

Huppertz C, Bartels M, Beijsterveldt CEM van, Boomsma DI, Hudziak JJ, Geus EJC de. Effect of Shared Environmental Factors on Exercise Behavior from Age 7 to 12 Years. Medicine & Science in Sports & Exercise. 2012;44(10):2025-2032, Open Access
DOI: 10.1249/MSS.0b013e31825d358e

Kan K-J, Boomsma DI, Dolan CV, Maas HLJ van der. Commentary: The presence of bifurcations as a ‘third component of individual differences’: implications for quantitative (behaviour) genetics. International Journal of Epidemiology. 2012;41(2):346-351, Free
DOI: 10.1093/ije/dyr222

Kort JM de, Dolan CV, Boomsma DI. Accommodation of genotype-environment covariance in a longitudinal twin design. Netherlands Journal of Psychology. 2012;67(3):81-90

Lamb DJ, Middeldorp CM, Beijsterveldt CEM van, Boomsma DI. Gene–environment interaction in teacher-rated internalizing and externalizing problem behavior in 7- to 12-year-old twins. Journal of Child Psychology and Psychiatry. 2012;53(8):818-825
DOI: 10.1111/j.1469-7610.2011.02497.x
Supplementary Materials (zip file)

Lamb DJ, Vink JM, Middeldorp CM, Beijsterveldt CEM van, Haak MC, Overbeek LIH, Boomsma DI. Effects of Chorionicity and Zygosity on Triplet Birth Weight. Twin Research and Human Genetics. 2012;15(2):149-157
DOI: 10.1375/twin.15.2.149

Lee PH, Perlis RH, Jung J-Y, Byrne EM, Rueckert E, Siburian R, Haddad S, Mayerfeld CE, Heath AC, Pergadia ML, Madden PAF, Boomsma DI, Penninx BWJH, Sklar P, Martin NG, Wray NR, Purcell SM, Smoller JW. Multi-locus genome-wide association analysis supports the role of glutamatergic synaptic transmission in the etiology of major depressive disorder. Translational Psychiatry. 2012;2(e184), Open Access
DOI: 10.1038/tp.2012.95
Supplementary Materials (zip file)

Ligthart L, Boomsma DI. Causes of Comorbidity: Pleiotropy or Causality? Shared Genetic and Environmental Influences on Migraine and Neuroticism. Twin Research and Human Genetics. 2012;15(2):158-165
DOI: 10.1375/twin.15.2.158

Lubke GH, Hottenga JJ, Walters R, Laurin C, Geus EJC de, Willemsen G, Smit JH, Middeldorp CM, Penninx BWJH, Vink JM, Boomsma DI. Estimating the Genetic Variance of Major Depressive Disorder Due to All Single Nucleotide Polymorphisms. Biological Psychiatry. 2012;72(8):707-709
DOI: 10.1016/j.biopsych.2012.03.011

Luciano M, Lopez LM, Moor MHM de, Harris SE, Davies G, Nutile T, Krueger RF, Esko T, Schlessinger D, Toshiko T, Penninx BWJH, Wright MJ, Heath AC, Duijn CM van, Bierut LJ, Raikkonen K, Martin NG, Ciullo M, Rujescu D, Boomsma DI, Deary IJ, others. Longevity Candidate Genes and Their Association With Personality Traits in the Elderly. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 2012;159B(2):192-200
DOI: 10.1002/ajmg.b.32013

Luciano M, Huffman JE, Arias-Vasquez A, Vinkhuyzen AAE, Middeldorp CM, Giegling I, Payton A, Davies G, Zgaga L, Janzing J, Hottenga JJ, Willemsen G, Hastie ND, Franke B, Boomsma DI, Martin NG, Rujescu D, Wilson JF, Buitelaar J, Pendleton N, Rudan I, Deary IJ, others. Genome-Wide Association Uncovers Shared Genetic Effects Among Personality Traits and Mood States. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 2012;159B(6):684-695
DOI: 10.1002/ajmg.b.32072
Supplementary Materials (zip file)

Manning AK, Hivert MF, Scott RA, Grimsby JL, Bouatia-Naji N, Chen H, Rybin D, Liu CT, Bielak LF, Prokopenko I, Hottenga JJ, Boomsma DI, Geus EJC de, Penninx BJWH, Willemsen G, Zemunik T, Zgaga L, Wareham NJ, McCarthy MI, Barroso I, Watanabe RM, Florez JC, Dupuis J, Meigs JB, Langenberg C, others. A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nature Genetics. 2012;44(6):659-669
DOI: 10.1038/ng.2274
Supplementary Materials (zip file)

McCrae RR, Willemsen G, Boomsma DI. Are parental personality traits a basis for mate selection? Journal of Research in Personality. 2012;46(4):455-457
DOI: 10.1016/j.jrp.2012.04.007

McEachin RC, Sannareddy KS, Cavalcoli JD, Karnovsky A, Vink JM, Sartor MA. Convergence of genetic influences in comorbidity. BMC Bioinformatics. 2012;13(Supplement 2):S8, Open Access
DOI: 10.1186/1471-2105-13-S2-S8
Supplementary Materials (zip file)

Middelberg RP, Benyamin B, Moor MHM de, Warrington NM, Gordon S, Henders AK, Medland SE, Nyholt DR, Geus EJC de, Hottenga JJ, Willemsen G, Beilin LJ, Mori TA, Wright MJ, Heath AC, Madden PAF, Boomsma DI, Pennell CE, Montgomery GW, Martin NG, Whitfield JB. Loci Affecting Gamma-Glutamyl Transferase in Adults and Adolescents Show Age X SNP interaction and Cardiometabolic Disease Associations. Human Molecular Genetics. 2012;21(2):446-455, Free
DOI: doi:10.1093/hmg/ddr478
Supplementary Materials (zip file)

Molenaar D, Sluis S van der, Boomsma DI, Dolan CV. Detecting Specific Genotype by Environment Interactions Using Marginal Maximum Likelihood Estimation in the Classical Twin Design. Behavior Genetics. 2012;42(3):483-499, Open Access
DOI: 10.1007/s10519-011-9522-x

Molenaar PCM, Smit DJA, Boomsma DI, Nesselroade JR. Estimation of Subject-Specific Heritabilities From Intra-Individual Variation: iFACE. Twin Research and Human Genetics. 2012;15(3):393-400
DOI: 10.1017/thg.2012.9

Mook-Kanamori DO, Beijsterveldt CEM van, Steegers EAP, Aulchenko YS, Raat H, Hofman A, Eilers PH, Boomsma DI, Jaddoe VWV. Heritability Estimates of Body Size in Fetal Life and Early Childhood. PLOS ONE. 2012;7(7):e39901, Open Access
DOI: 10.1371/journal.pone.0039901
Supplementary Materials (zip file)

Moor MHM de, Costa PT, Terracciano A, Krueger RF, Geus EJC de, Toshiko T, Penninx BWJH, Esko T, Madden PAF, Derringer J, Amin N, Willemsen G, Hottenga JJ, Distel MA, Janssens ACJW, Oostra BA, Metspalu A, Abecasis GR, Deary IJ, Räikkönen K, Bierut LJ, Martin NG, Duijn CM van, Boomsma DI, many others. Meta-analysis of genome-wide association studies for personality. Molecular Psychiatry. 2012;17(3):337-349
DOI: 10.1038/mp.2010.128
Supplementary Materials (zip file)

Nan C, Guo B, Warner C, Fowler T, Barrett T, Boomsma DI, Nelson T, Whitfield K, Beunen G, Thomis M, Maes HH, Derom C, Ordoñana J, Deeks J, Zeegers M. Heritability of body mass index in pre-adolescence, young adulthood and late adulthood. European Journal of Epidemiology. 2012;27(4):247-253
DOI: 10.1007/s10654-012-9678-6

Nürnberg ST, Rendon A, Smethurst PA, Paul DS, Voss K, Thon JN, Lloyd-Jones H, Sambrook JG, Tijssen MR, Hottenga JJ, Geus EJC de, Willemsen G, Boomsma DI, Italiano Jr JE, Deloukas P, Gottgens B, Soranzo N, Ouwehand WH. A GWAS sequence variant for platelet volume marks an alternative DNM3 promoter in megakaryocytes near a MEIS1 binding site. Blood. 2012;120(24):4859-4868
DOI: 10.1182/blood-2012-01-401893
Supplementary Materials (zip file)

Palmer ND, McDonough CW, Hicks PJ, Roh BH, Wing MR, Sandy An S, Hester JM, Cooke JN, Bostrom MA, Rudock ME, DIAGRAM Consortium, MAGIC Investigators, Ziegler JT, Sale MM, Divers J, Shriner D, Adeyemo A, Rotimi CN, Ng MCY, Langefeld CD, Freedman BI, Bowden DW, others. A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans. PLOS ONE. 2012;7(1):e29202, Open Access
DOI: 10.1371/journal.pone.0029202
Supplementary Materials (zip file)

Paternoster L, Standl M, Chen CM, Ramasamy A, Bønnelykke K, Duijts L, Ferreira MA, Couto Alves A, Thyssen JP, Albrecht E, Groen-Blokhuis MM, Australian Asthma Genetics Consortium, Hottenga JJ, Boomsma DI, The Genetics of Overweight Young Adults Consortium, Strachan DP, Martin NG, Jarvelin MR, Heinrich J, Evans DM, Weidinger S, many others. Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. Nature Genetics. 2012;44(2):187-192
DOI: 10.1038/ng.1017
Supplementary Materials (zip file)

Pelt S van, Boomsma DI, Fries P. Magnetoencephalography in Twins Reveals a Strong Genetic Determination of the Peak Frequency of Visually Induced Gamma-Band Synchronization. The Journal of Neuroscience. 2012;32(10):3388-3392
DOI: 10.1523/JNEUROSCI.5592-11.2012

Raalte DH van, Leeuwen N van, Simonis-Bik AMC, Nijpels G, Haeften TW van, Schafer SA, Boomsma DI, Kramer MHH, Heine RJ, Maassen JA, Staiger H, Machicao F, Häring HU, Slagboom PE, Willemsen G, Geus EJC de, Dekker JM, Fritsche A, Eekhoff EM, Diamant M, Hart LM ’t. Glucocorticoid receptor gene polymorphisms are associated with reduced first-phase glucose-stimulated insulin secretion and disposition index in women, but not in men. Diabetic Medicine. 2012;29(8):e211-e216
DOI: 10.1111/j.1464-5491.2012.03690.x
Supplementary Materials (zip file)

Robbers SC, Oort F van, Huizink AC, Verhulst FC, Beijsterveldt CEM van, Boomsma DI, Bartels M. Childhood problem behavior and parental divorce: evidence for gene–environment interaction. Social Psychiatry and Psychiatric Epidemiology. 2012;47(10):1539-1548, Open Access
DOI: 10.1007/s00127-011-0470-9

Scheet P, Ehli EA, Xiao X, Beijsterveldt CEM van, Abdellaoui A, Althoff RR, Hottenga JJ, Willemsen G, Nelson KA, Huizenga PE, Hu Y, Amos CI, Bartels M, Groen-Blokhuis MM, Geus EJC de, Hudziak JJ, Davies GE, Boomsma DI. Twins, Tissue, and Time: An Assessment of SNPs and CNVs. Twin Research and Human Genetics. 2012;15(6):737-745
DOI: 10.1017/thg.2012.61
Supplementary Materials (zip file)

Scott RA, Lagou V, Welch RP, Wheeler E, Montasser ME, Luan J, Mägi R, Strawbridge RJ, Rehnberg E, Gustafsson S, Hottenga JJ, Willemsen G, Geus EJC de, Penninx BWJH, Duijn CM van, Boomsma DI, Bouatia-Naji N, McCarthy MI, Franks PW, Meigs JB, Teslovich TM, Florez JC, Langenberg C, Ingelsson E, Prokopenko I, Barroso I, many others. Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nature Genetics. 2012;44(9):991-1005
DOI: 10.1038/ng.2385
Supplementary Materials (zip file)

Smit DJA, Boersma M, Schnack HG, Micheloyannis S, Boomsma DI, Hulshoff Pol HE, Stam CJ, Geus EJC de. The Brain Matures with Stronger Functional Connectivity and Decreased Randomness of Its Network. PLOS ONE. 2012;7(5):e36896, Open Access
DOI: 10.1371/journal.pone.0036896

Smit DJA, Ent D van 't, Zubicaray G de, Stein JL. Neuroimaging and Genetics: Exploring, Searching, and Finding. Twin Research and Human Genetics. 2012;15(Special Issue 3):267-272
DOI: 10.1017/thg.2012.20

Smit DJA, Boomsma DI, Schnack HG, Hulshoff Pol HE, Gewus EJC de. Individual Differences in EEG Spectral Power Reflect Genetic Variance in Gray and White Matter Volumes. Twin Research and Human Genetics. 2012;15(Special Issue 3):384-392
DOI: 10.1017/thg.2012.6

Soelen ILC van, Brouwer RM, Baal GCM van, Schnack HG, Peper JS, Collins DL, Evans AC, Kahn RS, Boomsma DI, Hulshoff Pol HE. Genetic influences on thinning of the cerebral cortex during development. NeuroImage. 2012;59(4):3871-3880
DOI: 10.1016/j.neuroimage.2011.11.044

Soelen ILC van, Brouwer RM, Peper JS, Leeuwen M van, Koenis MMG, Beijsterveldt CEM van, Swagerman SC, Kahn RS, Hulshoff Pol HE, Boomsma DI. Brain SCALE: Brain Structure and Cognition: an Adolescent Longitudinal Twin Study into the Genetic Etiology of Individual Differences. Twin Research and Human Genetics. 2012;15(Special Issue 3):453-467
DOI: 10.1017/thg.2012.4

Stein JL, Medland SE, Arias Vasquez A, Hibar DP, Senstad RE, Winkler AM, Toro R, Appel K, Bartecek R, Bergmann Ø, Hottenga JJ, Boomsma DI, Geus EJC de, Hulshoff Pol HE, Kahn RS, Penninx BWJH, Smoller JW, Wardlaw JM, Weale ME, Martin NG, Franke B, Wright MJ, Thompson PM, others. Identification of common variants associated with human hippocampal and intracranial volumes. Nature Genetics. 2012;44(5):552-561
DOI: 10.1038/ng.2250
Supplementary Materials (zip file)

Stolk L, Perry JRB, Chasman DI, He C, Mangino M, Sulem P, Barbalic M, Broer L, Byrne EM, Ernst F, Hottenga JJ, Geus EJC de, Vink JM, Willemsen G, Boomsma DI, Streeten EA, Thorsteinsdottir U, Uda M, Uitterlinden AG, Duijn CM van, Völzke H, Murray A, Murabito JM, Visser JA, Lunetta KL, many others. Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nature Genetics. 2012;44(3):260-268
DOI: 10.1038/ng.1051
Supplementary Materials (zip file)

Surakka I, Whitfield JB, Perola M, Visscher PM, Montgomery GW, Falchi M, Willemsen G, Geus EJC de, Magnusson PKE, Christensen K, Syvänen AC, Palotie A, Kaprio J, Kyvik KO, Pedersen NL, Boomsma DI, Spector T, Martin NG, Ripatti S, Peltonen L, others. A Genome-Wide Association Study of Monozygotic Twin-Pairs Suggests a Locus Related to Variability of Serum High-Density Lipoprotein Cholesterol. Twin Research and Human Genetics. 2012;15(6):691-699
DOI: 10.1017/thg.2012.63
Supplementary Materials (zip file)

Taal HR, St Pourcain B, Thiering E, Das S, Mook-Kanamori DO, Beijsterveldt CEM van, Groen-Blokhuis M, Hottenga JJ, Middeldorp CM, Willemsen G, Boomsma DI, Hakonarson H, Smith GD, Heinrich J, Jarvelin MR, Jaddoe VWV, others. Common variants at 12q15 and 12q24 are associated with infant head circumference. Nature Genetics. 2012;44(5):532-538
DOI: 10.1038/ng.2238
Supplementary Materials (zip file)

Talens RP, Christensen K, Putter H, Willemsen G, Christiansen L, Kremer D, Suchiman HED, Slagboom PE, Boomsma DI, Heijmans BT. Epigenetic variation during the adult lifespan: cross-sectional and longitudinal data on monozygotic twin pairs. Aging Cell. 2012;11(4):694-703, Open Access
DOI: 10.1111/j.1474-9726.2012.00835.x
Supplementary Materials (zip file)

Uh HW, Deelen J, Beekman M, Helmer Q, Rivadeneira F, Hottenga JJ, Boomsma DI, Hofman A, Uitterlinden AG, Slagboom PE, Böhringer S, Houwing-Duistermaat JJ. How to deal with the early GWAS data when imputing and combining different arrays is necessary. European Journal of Human Genetics. 2012;20(5):573-576, Open Access
DOI: 10.1038/ejhg.2011.231

Verbeek EC, Bakker IMC, Bevova MR, Bochdanovits Z, Rizzu P, Sondervan D, Willemsen G, Geus EJC de, Smit JH, Penninx BWJH, Boomsma DI, Hoogendijk WJG, Heutink P. A Fine-Mapping Study of 7 Top Scoring Genes from a GWAS for Major Depressive Disorder. PLOS ONE. 2012;7(5):e37384, Open Access
DOI: 10.1371/journal.pone.0037384

Vink JM, Bartels M, Beijsterveldt CEM van, Dongen J van, Beek JHDA van, Distel MA, Moor MHM de, Smit DJA, Minica CC, Ligthart L, Geels LM, Abdellaoui A, Middeldorp CM, Hottenga JJ, Willemsen G, Geus EJC de, Boomsma DI. Sex Differences in Genetic Architecture of Complex Phenotypes? PLOS ONE. 2012;7(12):e47371, Open Access
DOI: 10.1371/journal.pone.0047371
Supplementary Materials (zip file)

Vliet-Ostaptchouk JV van, Haeften TW van, Landman GWD, Reiling E, Kleefstra N, Bilo HJG, Klungel OH, Boer A de, Diemen CC van, Wijmenga C, Simonis-Bik AM, Eekhoff EMW, Diamant M, Kramer MHH, Boomsma DI, Geus EJC de, Willemsen G, Slagboom PE, Hofker MH, Hart LM ’t, others. Common Variants in the Type 2 Diabetes KCNQ1 Gene Are Associated with Impairments in Insulin Secretion During Hyperglycaemic Glucose Clamp. PLOS ONE. 2012;7(3):e32148, Open Access
DOI: 10.1371/journal.pone.0032148
Supplementary Materials (zip file)

Webb BT, Guo A-Y, Maher BS, Zhao Z, Oord EJ van den, Kendler KS, Riley BP, Gillespie NA, Prescott CA, Middeldorp CM, Willemsen G, Geus EJC de, Hottenga JJ, Boomsma DI, Fyer AJ, Huezo-Diaz P, McGuffin P, Farmer A, Craig IW, Lewis C, Sham P, Crowe RR, Flint J, Hettema JM, others. Meta-analyses of genome-wide linkage scans of anxiety-related phenotypes. European Journal of Human Genetics. 2012;20(10):1078-1084
DOI: 10.1038/ejhg.2012.47
Supplementary Materials (zip file)

Wray NR, Pergadia ML, Blackwood DHR, Penninx BWJH, Gordon SD, Nyholt DR, Ripke S, Macintyre DJ, Hottenga JJ, Willemsen G, Middeldorp CM, Geus EJC de, Medland SE, Statham DJ, Henders AK, Heath AC, Montgomery GW, Martin, Boomsma DI, Madden PAF, Sullivan PF, others. Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned. Molecular Psychiatry. 2012;17(1):36-48, Open Access
DOI: 10.1038/mp.2010.109
Supplementary Materials (zip file)

Yang J, Loos RJF, Powell JE, Medland SE, Speliotes EK, Chasman DI, Rose LM, Thorleifsson G, Steinthorsdottir V, Mägi R, Hottenga JJ, Willemsen G, Vink JM, Duijn CM van, Geus EJC de, Boomsma DI, Penninx BWJH, Strachan DP, Hill WG, Snieder H, Ridker PM, Thorsteinsdottir U, Stefansson K, Frayling TM, Hirschhorn JN, Goddard ME, Visscher PM, others. FTO genotype is associated with phenotypic variability of body mass index. Nature. 2012;490(7419):267-272
DOI: 10.1038/nature11401
Supplementary Materials (zip file)

Zeeuw EL de, Beijsterveldt CEM van, Geus EJC de, Boomsma DI. Twin Specific Risk Factors in Primary School Achievements. Twin Research and Human Genetics. 2012;15(2):107-115
DOI: 10.1375/twin.15.1.107